RNA Supply Chain Resources

  1. CRISPR sgRNA For Successful Gene Editing: Discovery To Clinic 9/25/2023

    The single guide RNA (sgRNA) is one of the key components of successful CRISPR gene editing. Here we cover all the important aspects of sgRNA and Synthego’s sgRNA products.

  2. Pre-Banking And Avoiding Manufacturing Challenges For GMP Plasmids Containing Unstable Sequence Regions 4/21/2021

    Ensuring consistent replication and proper retention of plasmid DNA sequence is vital to the economics and efficiency in generating starting materials used for production of AAV delivered gene therapy and mRNA vaccines and therapeutics.

  3. Chromatographic Purification Of Plasmid DNA 11/19/2020

    Widespread application of pDNA in gene therapy is driving increased demand and as a response, plasmid manufacturing must become more efficient with improved productivity. Intensification of chromatographic steps can help address this demand and has led to an exploration of the use of convective media (monoliths, membranes, fibre based technologies).

  4. Key Challenges for CRISPR In Clinical Development 2/28/2023

    Learn how to approach CRISPR cell and gene therapy development challenges, such as regulatory hurdles, ensuring consistency, finding qualified and experienced staff, and obtaining GMP-Grade reagents.

  5. Supercharge Your Supply Chain: Harness AI To Gain Competitive Advantage

    The success of CGTs hinges upon adherence to specific logistics protocols. Learn how the integration of AI in the pharma supply chain is poised to enhance visibility, efficiency, and compliance.

  6. Delivering Global Media Manufacturing Consistency Through Site-To-Site Equivalency 7/8/2024

    Explore a program focused on achieving process consistency through risk mitigation in four key areas: raw materials sourcing, equipment, manufacturing processes, and finished product testing.

  7. Transitioning From Using RUO To cGMP Chemicals For Clinical Trials 10/17/2023

    Learn about the common challenges and risks associated with accelerating your molecule's timeline from lab to clinic, along with important supply chain considerations for emerging biopharma companies.

  8. Revolutionizing Patient-Centric Supply Chains To Improve Vaccine Access 3/1/2023

    Transparent collaboration and innovation are essential to establishing an infrastructure that supports more agile business models and empowers widespread vaccine access.

  9. Where Can Novel Non-Viral Polymeric Delivery Agents Take Us? 1/18/2023

    Explore ongoing work to harness different types of HDR templates in order to build cutting-edge systems with the potential to enable point-of-care cell and gene therapy manufacture.

  10. The Source Of GMP- How Client Demand Drives Innovation 1/13/2021

    GMP-Source, which is a term we coined, serves the purpose as a highly qualified raw material for a generation of virus, messenger RNA template, and transgenic expression of proteins.