RNA Formulation Articles

1. Beyond Protein Targets: Why The Regulatory Genome Could Redefine RNA Medicine (Pt. 1) 8/4/2026

   Explore how the regulatory genome and lncRNAs are shifting RNA medicine beyond protein targets, enabling cell-state reprogramming to treat disease at its source.

2. Beyond Better Models: Why The Future Of AI-Designed mRNA Depends On More Relevant Biological Data 7/31/2026

   AI can optimize mRNA only if it's trained on biologically relevant data. Better therapeutic datasets — not just better algorithms — will drive the next generation of RNA medicines.

3. The Delivery Challenge For In Vivo Cell Engineering 7/30/2026

   As RNA therapies expand beyond the liver, delivery—not payload design—has become the defining challenge for precise, scalable in vivo cell engineering.

4. Building An ASO For TUBB4A-Related Leukodystrophy (Pt. 1) 7/28/2026

   SynaptixBio CEO Dan Williams explains how the company selected an ASO for TUBB4A leukodystrophy by balancing potency, safety, and translational rigor to advance a rare disease therapy.

5. Location Matters: How The Nuclear Geography Of circRNAs Could Shape The Future Of RNA Therapeutics 7/23/2026

   CircRNA location may be as important as its sequence. Discover how nuclear organization could influence the next generation of RNA therapeutics.

6. Building The RNA Knowledge Graph: How Better Annotation Is Accelerating Therapeutic Discovery 7/22/2026

   As RNA therapeutics grow more complex, better biological annotation is becoming the foundation for AI-driven discovery, target selection, and smarter drug development.

7. Building A Self-Driving Lab For LNP Development 7/20/2026

   With commercially available components, MIT researchers built a platform that accelerates LNP process development, optimization, and autonomous manufacturing research.

8. Beyond Vaccines: Can RNA Sense Gases? 7/20/2026

   Could RNA sense its environment? A new hypothesis explores how RNA may detect temperature and gases, inspiring smarter, adaptive RNA therapeutics.

9. Decoding RNA's Circular Decisions: How HNRNPD Shapes circRNA Biogenesis And RNA Fate 7/17/2026

   How do cells decide between circular and linear RNA? New insights into HNRNPD reveal mechanisms that could improve the design of future circRNA therapeutics.

10. Beyond Gene Silencing: Harnessing Regulatory RNAs To Increase Gene Expression In Haploinsufficient Disease 7/16/2026

    Can RNA therapeutics increase — not silence — gene expression? Regulatory RNA-targeting ASOs may redefine treatment for haploinsufficient diseases.