Featured Articles

  1. mRNA Product Purification Process Strategies 2/15/2023

    Impurities from IVT can induce undesired immune responses and negatively impact translation efficiency. Explore the pros and cons of each option for mRNA purification.

  2. mRNA Product IVT Process Insights 2/15/2023

    In vitro transcription (IVT) allows a researcher to tailor synthesis and introduce modifications to produce a transcript. Learn about IVT along with process challenges and strategies.

  3. mRNA: Challenges And Strategies Related To The DNA Template Process 2/15/2023

    Encapsulated mRNA–LNP creation begins with synthesizing the DNA template. Explore insights on DNA template synthesis, the challenges and strategies of generating a DNA template using PCR, and more.

  4. Introduction To mRNA Manufacturing 2/15/2023

    The SARS-CoV-2 virus has changed the course of scientific research around mRNA. Learn about mRNA manufacturing, the structure of a mRNA molecule, RNase-free considerations, and more.

  5. mRNA Manufacturing: Overcoming CMC Development Challenges 6/15/2022

    A lack of standardization and cost-effective techniques for manufacturing and analytics for product characterization create CMC challenges for mRNA-based products.

  6. New To mRNA Manufacturing? Considerations For Starting 6/15/2022

    Explore considerations for starting mRNA manufacturing related to the following topics: DNA template, mRNA product - IVT, mRNA product - purification, LNP encapsulation, and fill-finish.

  7. Oligonucleotide Development And Manufacturing Workflow 3/28/2022

    Learn more about oligo workflows and solutions for oligonucleotide process development, from scalable oligo synthesis to cleavage and deprotection, purification, and buffer exchange.

  8. Outsourcing Process Development: Key Considerations For Biopharma 3/14/2022

    In Best Practices for Outsourcing Process Development, a panel of experts discussed four themes that may help drive the best outcomes when vetting process development service providers.

  9. Genomic Medicine And The Tools To Realize Its Potential 1/12/2022

    New technologies and collaborations driving the democratization of RNA therapeutics are creating an explosion of opportunity for companies pursuing the development of these transformative medicines.

  10. Key Insights Into Overcoming mRNA Process Challenges 9/8/2021

    Realizing the potential of mRNA requires focus on key areas and strategies that could help alleviate the bottlenecks in this growing market segment.