Newsletter | March 18, 2026

03.18.26 -- The 2026 RNA Investment Landscape

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Join Advancing RNA Chief Editor Anna Rose Welch on March 26 at 11 am ET for Advancements in gRNA Manufacturing & Quality. In this discussion with our knowledgeable panelists, we’ll dig into where the biggest gaps remain in our understanding of guide RNA quality and what improvements to the analytical toolbox/manufacturing paradigm need to be made to improve the overall understanding and quality of guide RNA. Register for free today.

FEATURED EDITORIAL

The Trough Of Disillusionment: 2026 RNA Reality Checks

Welcome to Advancing RNA’s mRNA Hot Takes, the show where we talk about serious RNA things, but with a spicy twist. Here, in episode 3, Advancing RNA's ARW sits down with Radar Therapeutics' Sophia Lugo and Entrée Bio's Michelle Lynn Hall to call out the "hyped" and "not hyped enough" topics of conversation for the RNA space in 2026.

2026 RNA Investment Landscape: Recent Deals, IPOs, And Venture Trends

As RNA investing matures, capital is flowing toward delivery, durability, and regulatory credibility. This column breaks down the deals, IPO signals, and venture theses shaping RNA’s 2026 winners—and why.

Benchmarking RNA Delivery Performance: Toward Standardized Metrics For Translational Success

As RNA pipelines mature, delivery success demands shared benchmarks. This article proposes standardized, stage-specific metrics to compare platforms, guide optimization, and strengthen regulatory confidence.

Overcoming Lung Tumor Barriers: Nanoparticle Delivery Strategies For Pulmonary Cancers

Solid lung tumors have a complex tumor microenvironment that creates barriers to drug delivery. Nanoparticle therapies can overcome these challenges.

INDUSTRY INSIGHTS

Analytical Method Release And Stability Platform For RNA Drug Substance

Access comprehensive analytical support across the research and development lifecycle. This platform includes method validation and GMP release testing to ensure high-quality RNA drug substances.

Reducing Technical Risk In mRNA Therapeutic Development

Advancements in purification and delivery mechanisms are essential for the future of mRNA. Improving stability during storage and transport helps mitigate risk and ensures therapeutic efficacy.

Engaging Early In Process Development To Bring mRNA Sequences To Life

Examine why template sequence characteristics are relevant for cGMP manufacturing of high-quality mRNA and consider insights on how to develop a scalable, robust, and economically viable process.

Quality In GMP IVT mRNA Development, Manufacturing, And Analytics

Stay ahead in mRNA therapeutic development by mastering the essential quality systems, process controls, and analytical methods required for robust GMP production and efficient manufacturing.

Accelerate LNP Manufacturing With Automated Process Development

Manual LNP formulation introduces process variability that threatens particle quality and yield. As programs scale toward clinical production, maintaining strict control over CQAs becomes essential.

5 Questions That Put Sponsors Back In Control Of Bioanalysis Projects

Bioanalysis service quality significantly impacts project success. Don't settle for typical CRO claims; demand better technology, pricing transparency, and dedicated partnership.

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5th Circular & Self‑Amplifying RNA Therapeutics Summit

This May, the 5th Circular & Self‑Amplifying RNA Therapeutics Summit is returning to Boston. This is the only meeting dedicated exclusively to circular and self‑amplifying RNA, bringing together senior biotech and pharma leaders working on next‑generation RNA therapeutics. As an Advancing RNA subscriber, you get 10% off! Just use code AdvancingRNA10 at checkout to enjoy a discount on all tickets.

SOLUTIONS

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