Newsletter | April 9, 2025

04.09.25 -- Is The mRNA Payload The Real MVP Of Targeted Delivery?

FEATURED EDITORIAL

Is The mRNA Payload The Real MVP Of Targeted Delivery?

As one delightfully colorful quote from a panel discussion at the AMM Ascent meeting last fall reminds us, there’s a lot more to be explored, discussed, and understood as it relates to the mRNA cargo’s role in targeted delivery. 

Tessera Therapeutics Advances In Vivo Gene Therapy For SCD

Tessera Therapeutics' CSO, Michael Holmes, Ph.D., shares information on the company's Gene Writers for sickle cell disease (SCD) and how their work has garnered investment from the Bill & Melinda Gates Foundation to support their efforts.

SPONSOR

The 4th Circular & Self-Amplifying RNA Therapeutics Summit is returning this May to unite leading next-generation RNA stakeholders, including the likes of Sail Biomedicines, Merck, Novo Nordisk, and more. This is the only industry-dedicated event showcasing the latest approaches and applications for more potent and durable treatment of a wide array of diseases to gain actionable insights for fast-tracking your RNA programs.

INDUSTRY INSIGHTS

Comparison Of HIC Monolithic Support For Sample Displacement Of pDNA

Unlock higher pDNA purity. Discover how three monolithic supports tackle the challenge of separating crucial plasmid isoforms without excessive ammonium sulfate.

mRNA-Focused Regulatory Expertise And CMC Document Preparation

Learn the regulatory requirements for mRNA drug substances and products, the importance of phase-appropriate quality, and insights on creating CMC documentation to ensure compliance.

Insights Into GMP Manufacturing Of RNA-LNP Drug Products

Explore key considerations for manufacturing RNA-LNP drug products surrounding process and analytical development, automation, environmental monitoring, and strategic collaborations.

Quality Concepts In GMP IVT mRNA Development, Manufacturing, Analytics

Stay ahead in mRNA therapeutic development by mastering the essential quality systems, process controls, and analytical methods required for robust GMP production and efficient manufacturing.

Analysis Of LNP Lipids With Evaporative Light Scattering Detection

Jump into this thorough analysis of lipids in LNP formulations using HPLC, a technique crucial for quality control in the production of mRNA vaccines and therapeutics.

A Multiplexed High Throughput Method To Evaluate Novel Nuclease Activity

Efficiently evaluating the activity of novel nucleases with unique properties requires a high-throughput, multiplexed approach that enables direct comparison across multiple genomic targets.

Accelerating Clinical Research And Outbreak Response With Automation, AI

Explore AI-driven automation and organ-on-a-chip technology to accelerate infectious disease research, enhancing assay efficiency, and improving vaccine and therapeutic development for emerging global health threats.