Newsletter | October 28, 2026

10.28.26 -- Is mRNA Manufacturing Overbuilt?

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RNA therapeutics are moving beyond scientific promise and into an era defined by scalable execution. Explore expert perspectives on the technologies, strategies, and partnerships shaping the future of RNA across vaccines, oncology, cell therapies, gene editing, and personalized medicine. From overcoming delivery challenges to advancing manufacturing, analytics, and commercialization, this collection examines the key decisions driving progress across the RNA landscape. Click to access the full collection of insights.

FEATURED EDITORIAL

Why RNA–LNP Development Needs Higher-Resolution Analytics In 2027

Raising analytical resolution is among the cheapest interventions available. With regulators tightening and capital selective, it is also among the most consequential.

Are We Missing mRNA Drug Substance CQAs?

As a field, we’ve been aligned around CQAs for our mRNA drug substances. However, differences in translation between highly similar mRNAs (i.e., same sequence, same design, different manufacturers) raise the question of whether we’re missing any QAs/CQAs. Advancing RNA Live panelists Elaine Peters and Ilya Shestolapov share their take. 

Is mRNA Manufacturing Overbuilt?

mRNA pipelines continue to advance, but has provider growth outpaced the pipeline? Let's take a closer look.

Can Chemical Engineering Unlock Solid Tumor Delivery?

We discuss how selective albumin binding improved tumor delivery in preclinical studies and what these findings could mean for the future of siRNA-based cancer therapies.

INDUSTRY INSIGHTS

xRNA Production: The Economic Case For Continuous Manufacturing

See how a continuous manufacturing platform streamlines production to days, uses real-time quality control, and dramatically cuts costs to accelerate access to new therapies.

How Hybrid Silica Solves Stability Challenges In Oligonucleotides

Discover how hybrid silica technologies ensure stability and high resolution in IP-RP chromatography applications while protecting instrumentation from excessive wear and tear.

The Cost Of Redundant Requalification In Therapy Expansion

Redundant requalification tasks can delay late-stage clinical expansion. Standardized protocols reduce repeat validation, lower costs, maintain quality, and support commercialization.

Customized mRNA Processing To Improved Development And Manufacturing

Optimize mRNA development by learning key strategies for process refinement, critical component identification, and in-process analytics to enhance therapeutic production.

Determining RNA Integrity And Purity By Capillary Gel Electrophoresis

To ensure mRNA product quality, it's important to confirm the integrity of the RNA. Examine the results of a study challenging the performance of the CGE method in assessing mRNA integrity and purity.

Modulate mRNA Therapy Effectiveness Using Modified Ribonucleotides

Learn about the problem of immunogenicity of mRNA, modified mRNA via in vitro transcription production, and choosing fit-for-purpose modified ribonucleotides.

SOLUTIONS

HPLC Made For Tomorrow

mRNA Process And Cost Modeling: A Tool To Optimize Process Development

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