Newsletter | May 21, 2025

05.21.25 -- Do We Really Understand Plasmid Quality's Effects On mRNA Production?

SPONSOR

Your Roadmap For Efficient Processes

Facing challenges with mRNA integrity? In this video, we reveal essential solutions for enhancing mRNA stability in mRNA manufacturing. Explore our new DTT and Spermidine endonuclease-free chemicals that enhance efficiency and stability. Watch now to discover more!

FEATURED EDITORIAL

Do We Really Understand Plasmid Quality's Effects On mRNA Production?

Two experts examine the current guidelines and specs for plasmid DNA and question whether our understanding is sufficient.

The Importance Of Automation & Digital Innovations In mRNA Production

In this segment of an Advancing RNA Live panel discussion, experts from Life Edit Therapeutics, Tune Therapeutics, and University of Sheffield share their perspectives on the role automation and digital tools (i.e., soft sensors, digital twins) can play in helping us better control our manufacturing processes.

INDUSTRY INSIGHTS

High-Sensitivity IVT mRNA Analysis

Quality analysis of in vitro transcribed (IVT) has become an essential part of biotherapeutic workflows. Discover a high-sensitivity kit made for analyzing IVT mRNA quality to advance your research.

Leveraging Single-Use Technology For mRNA-LNP Drug Manufacturing

Single-use technology is vital for ensuring the quality and expedited market entry of genomic medicines. Learn how LNP technology is paving the way for a new era of personalized, precise medicine.

Demand More From Your Oligo Synthesizer

The market for oligonucleotide therapeutics is expanding, and the pipeline is diverse. Gain insight into how you can fast-track your molecule's development with verified synthesizers, columns, and scientific support and expertise.

CMC Document Preparation To Support mRNA Therapeutic Development

Explore the regulatory requirements for mRNA drug substances and products, the importance of phase-appropriate quality, and insights on creating CMC documentation to ensure compliance.

Oligonucleotides: Where We Are And Where We Would Like To Go

This presentation provides an overview of oligonucleotide bioanalysis's current status and future directions. We will look into the advantages and disadvantages of various bioanalytical techniques.

Development And Optimization Of LNP Formulations

The production of lipid nanoparticles (LNPs) is a process that demands robustness, scalability, and reproducibility. Examine the impact of key operational parameters on the efficacy of LNPs.

Study Viral Infection In Resting Human CD4+ T Cells

Explore a study proving how synthetic single guide RNAs were used to optimize the editing conditions for resting human CD4+ T cells and maintain high cell viability for several weeks post Nucleofection.

SPONSOR

Webinar: Turbulent Times: How to successfully control the upscaling of your LNP formulation with KNAUER’s Impingement Jet Mixing

KNAUER’s webinar on Lipid Nano Particles (LNPs) covers fundamentals, formulation challenges, and upscaling strategies. Topics include lipid composition, mixing techniques like IJM, and GMP compliance. Designed for professionals, it offers insights into efficient, scalable LNP production from lab to industrial scale. Click here to learn more.