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| Personalized cancer vaccines are pushing immuno-oncology forward, but delivery and manufacturing hurdles still stand in the way. In this webinar, Cytiva explores how optimized ionizable LNPs can improve mRNA vaccine delivery, tolerability, and tumor response, while supporting small-scale clinical manufacturing strategies that help move PCV candidates from concept to clinic with greater confidence. Click here to learn more. |
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By Anna Rose Welch, Advancing RNA | How are we defining and measuring our product’s potency? This question, posed at a past CASSS mRNA Symposium, is far from straightforward, and, dear reader, based on the resulting discussion amongst regulators and panel members, it became clear we have a lot of different definitions of what potency even is in the mRNA space. | |
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Plausible Mechanism Framework Changes Rare Disease Drug Development | By Leila Cupersmith, Choice ClinOps | Discover how the new FDA Plausible Mechanism Framework changes the game for rare disease research. This shift addresses unconventional programs by formalizing an approval pathway for individualized treatments of ultra-rare genetic diseases. |
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How Microfluidics And QbD Are Maturing LNP Manufacturing | By Advancing RNA Live | CMC Consultant Sujit Jain and NanoVation CEO Dominik Witzigmann share their perspectives on the manufacturing technology advancements that have and will continue to meaningfully improve passive delivery of mRNA-LNPs. |
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| Optimize Your Performance Model For mRNA Yield And Quality | Application Note | Roche CustomBiotech | Enhance your mRNA production by identifying optimal reaction conditions. Ascertain how to utilize a design of experiment approach to reliably achieve high-quality mRNA in significantly higher yields. |
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| How Polymerase Selection Shapes IVT Outcomes | Case Study | Primrose Bio | dsRNA contamination starts with polymerase choice. See how engineered RNA polymerases cut dsRNA by more than 10x compared to wild-type T7 in independent IVT testing. |
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