Newsletter | December 17, 2025

12.17.25 -- Critical Discussions Driving The mRNA Industry's Next Chapter

SPONSOR

Webinar: The mRNA Journey: From Design to LNP-Ready Molecules for Research

Discover an optimized end-to-end workflow for producing high-quality IVT mRNA for research applications. This Agilent webinar covers every step—from sequence design and PCR-based DNA template preparation to transcription, lipid nanoparticle formulation, and QC testing with Agilent TapeStation and Fragment Analyzer systems—enabling fast, reliable, small-scale mRNA production for non-clinical research such as vaccines, protein expression, and gene or cell therapy. Watch it here.

FEATURED EDITORIAL

Striking The Right Balance: The Critical Discussions Driving The mRNA Industry's Next Chapter

Now, I cannot claim that I or any of the panelists at CASSS have or had access to a real crystal ball that will show us the future. However, what did come through these discussions loud and clear is that the future of our industry must include “balance.” Here, I’ll unpack a few ways the theme of “balance” presented itself — and no doubt will continue to present itself in the future — as well as how the panelists see us achieving this necessary balance. 

Emerging RNA Delivery Strategies For Solid Tumor Oncology

RNA shows promise in solid tumors, but delivery remains the core challenge. New targeting and delivery strategies aim to overcome tumor barriers and unlock RNA’s full therapeutic potential.

The Purification Dilemma: Balancing Upstream & Downstream Investment

This Advancing RNA Live clip dives into the biggest challenges in mRNA purification and the critical debate on where to focus investment. Here, our three mRNA PD experts argue for a holistic process development strategy, challenging the traditional wisdom of optimizing the upstream process at any cost.

The 9 Fastest-Growing Outsourcing Segments

Capacity isn’t the choke point—capability is; this piece ranks nine fast-growing outsourcing segments and shows sponsors how to win by locking in modality-proven partners early.

INDUSTRY INSIGHTS

Early Spectroscopic Insights Into RNA Modifications In LNP Formulations

Understand how Microfluidic Modulation Spectroscopy (MMS) provides early insights into RNA degradation within LNP formulations, offering a label-free approach to monitoring chemical integrity.

How To Select The Right Bioanalysis CRO For Your Program

The right CRO can be a strategic accelerator, while the wrong one can slow progress and jeopardize outcomes. When every provider promises speed and credibility, how can you identify your ideal partner?

Practical Applications For Controlled And Safe Nucleic Acid Delivery

Gain insight into LNP formulation development, from ionizable lipids to scalable manufacturing through case studies, screening strategies, and more for advancing next-generation therapeutics.

The Absolute Essentials Of Manufacturability

Read why integrating Quality by Design (QbD) and Process Analytical Technology (PAT) early on is essential for developing a robust, controlled, and financially viable process.

Empowering Patients And Tackling Orphan Drug Development Challenges

Successful rare disease trial design requires patient-centric approaches. Experts share how to embed the patient voice, optimize site readiness, and balance feasibility with essential regulatory rigor.

Customized mRNA Processing For Therapy Development And Manufacturing

Optimize mRNA development by learning key strategies for process refinement, critical component identification, and in-process analytics to enhance therapeutic production.

Lowering The Lipid Barrier To RNA-LNP Therapeutics

Industry experts discuss current and future trends, formulating successful lipid compositions and navigating the constantly evolving genomic medicine landscape.

Best Practices For Analysis Of In Vitro Transcribed (IVT) mRNA

Find out the best practices for high-resolution analysis of IVT RNA using automated capillary electrophoresis. Improve accuracy and precision in quantifying critical quality attributes.

Empowering A New Era Of Patient-Centric Medicines

Discover the challenges pharma companies are facing as they switch focus as well as the actions and technologies companies are implementing to help achieve a brighter future for patients.

Insights Into GMP Manufacturing Of RNA-LNP Drug Products

Explore key considerations for manufacturing RNA-LNP drug products surrounding process and analytical development, automation, environmental monitoring, and strategic collaborations.

Expand Your Toolbox For Quality mRNA Manufacturing

Review these guidelines for the use of SP6 RNA Polymerase in mRNA synthesis to determine if is a good alternative for your specific template and optimize your process.

Building Local Biomanufacturing Capacity In South Africa

Biovac evolved from a vaccine supplier to a biopharmaceutical innovator, providing a blueprint for expanding Africa's vaccine manufacturing capacity. Gain valuable insights from their journey.

JHS And Groninger's Partnership Drives Pharma Innovation And Growth

JHS and groninger’s partnership powers expansion with advanced aseptic filling lines, driving innovation, quality, and community growth through shared values and strategic collaboration.

SPONSOR

Translating Novel siRNA & microRNA Drugs from Bench To Bedside

Returning as the industry's premier dedicated forum, the 7th RNAi-Based Therapeutics Summit is the only event uniting the entire RNA interference ecosystem to translate the next wave of siRNA and microRNA drugs from bench to bedside. It will go beyond the liver, focusing on the novel strategies turning extra-hepatic delivery into a clinical reality. Find Out More.

SOLUTIONS

Meet The Latest Member Of The Oligo Synthesis Family

Quantitative PCR (qPCR)

Sodium Hydroxide: NaOH 1M In 20 L Bag

Biologics Manufacturing

Labscale Lipid Nanoparticle Production