Early Spectroscopic Insights Into RNA Modifications In LNP Formulations With Microfluidic Modulation Spectroscopy

Lipid nanoparticles (LNPs) are crucial for mRNA therapeutics, yet their ionizable lipids, like SM-102, can degrade mRNA through oxidative decomposition and covalent modification of nucleobases. Standard analysis methods are often time-consuming and require extensive cleanup, making it challenging to differentiate various degradation pathways.

This application note showcases how UV-Vis spectroscopy and Microfluidic Modulation Spectroscopy (MMS) offer a direct, label-free approach to monitor RNA chemical integrity under formulation-like conditions, providing early spectroscopic insights into these degradation processes. Download the full application note to learn more about these powerful techniques.