RNA Manufacturing Videos

  1. Why We Still Haven't Solved mRNA Scale-Up 10/15/2025

    While we can make lots of mRNA at a smaller scale, when it comes to scaling up to kg quantities of mRNA, our current batch processes leave a lot to be desired. Together, Stu Sundseth of Tune Therapeutics and Christian Dohmen of Ethris unpack the biggest barriers to scaling IVT to achieve the desired yield and quality of mRNA, offering their take on how the field is innovating to overcome these issues. 

  2. Sustainable Approaches To Oligonucleotide Manufacturing

    An industry expert shares about sustainable Oligo manufacturing approaches that can save time, cost, and resources – while improving purity, quality, and scalability of these promising therapeutics.

  3. Quality Through Innovation 3/20/2026

    Early‑stage engineering shapes reliable, user‑focused systems. See how an electrical engineer refines concepts, tests new ideas, and aligns each design update with the practical needs of the team.

  4. Advanced Single-Use Mixing Systems 11/9/2021

    The Mobius® MIX single-use mixing systems delivers advanced technology to make and purify plasmid DNA and mRNA.

  5. Shaping Therapeutic Development With Cutting-Edge CRISPR Nucleases 6/4/2025

    Gain an understanding of how an advanced nuclease portfolio is designed to support CRISPR-based cell and gene therapy development, providing scientists with the best solutions for therapeutic success.

  6. Effective, Efficient Downstream Purification For Plasmid DNA 4/26/2022

    Learn about a complete purification process flow that overcomes the challenges of producing pDNA – a critical first step in mRNA manufacturing – and covers all downstream unit operations.

  7. Are We Missing mRNA Drug Substance CQAs? 6/9/2026

    As a field, we’ve been aligned around CQAs for our mRNA drug substances. However, differences in translation between highly similar mRNAs (i.e., (same sequence, same design, different manufacturers) raises the question of whether we’re missing any QAs/CQAs. Here, Advancing RNA Live panelists Elaine Peters and Ilya Shestolapov share their take. 

  8. Modular Liquid Nanoparticle (LNP) Systems 12/6/2024

    Optimize your lipid nanoparticle (LNP) production with KNAUER's modular systems. Maximize flexibility, scalability, and control to meet the needs of your project.

  9. TakeOne® Aseptic Sampling System

    The TakeOne® is a single-use, pre-assembled sampling device for aseptic collection of samples during upstream and downstream process steps. It is ideal for critical endotoxin, bioburden, sterility and purity checks.

  10. Streamline Your mRNA Purification Steps 3/4/2025

    Ensure your mRNA's stability and effectiveness post-transcription with advanced filtration and chromatography techniques to enhance purity and recovery, which delivers high-quality mRNA for superior therapeutics and vaccines.