RNA Formulation Videos

1. Durable Liquid Nanoparticle (LNP) Systems 12/6/2024

   Discover the benefits of an LNP system that offers unparalleled durability and sustainability. Eliminate wear parts, plastic waste, and running costs with a system designed for long-term performance and minimal environmental impact.

2. Goldilocks & The 3…CQAs? Finding "Just Right" With LNP Optimization 12/4/2024

   Three LNP experts from Sanofi, Hopewell Therapeutics, and BioNTech collectively discuss how far we’ve come in understanding the structure of our LNPs while also shedding light on the variables that have the greatest potential of causing shifts in our products’ structure/function.

3. R&D & CMC Priorities For LNPs Beyond Cell-Specific Delivery 12/4/2024

   It goes without saying that achieving cell-specific delivery is the most often discussed challenge facing the RNA-LNP field near- and long-term. However, as these three LNP experts share in this Advancing RNA Live clip, they have a whole list of additional R&D and CMC priorities we must address/accomplish to improve RNA-LNPs’ efficacy in personalized and gene therapy approaches.

4. The State of the Linear mRNA Supply Chain—In Brief

   In this clip, Sanofi’s Greg Troiano kickstarts our discussion on some of the advances he’s seen in the supply chain for linear mRNA-LNP products, both in terms of supply availability and supplier capability.

5. How To Bring (Any) mRNA To Life: Simplifying Nucleic Acid Encapsulation 5/6/2024

   New technologies for the encapsulation of nucleic acids, such as FDmiX, can potentially overcome limitations of currently available standard mixing technologies.

6. Advancements In LNP CMC: What Are The Current "Known Knowns"? 12/4/2024

   In this Advancing RNA Live clip, Sanofi’s Sumit Luthra highlights the learnings we’ve made to-date about how our processes — both in terms of unit operations and process conditions — inform our LNP composition/heterogeneity.

7. Lipid Nanoparticle (LNP) Production Systems 12/6/2024

   Discover cutting-edge equipment featuring high-pressure dosing technology that enables the efficient production of LNPs for diverse applications.

8. Q&A On Formulation & Stability Of LNPs 11/28/2022

   Russell Johnson, VP Formulation Research for RVAC Medicines, and Aalok Shah, Director of Formulation & Drug Delivery, Strand Therapeutics, address audience questions around the importance of drug substance and drug product stability in efficient delivery in this segment of the Bioprocess Online Live! event LNPs & Beyond: Opportunities in RNA Delivery.

9. How To Successfully Control The Upscaling Of Your LNP Formulation 5/28/2025

   Discover key strategies for controlling LNP formulation and upscaling. Explore the science behind lipid nanoparticles, critical parameters, and achieving effective turbulent mixing for optimal outcomes.

10. How To Manufacture LNPs On The Nova Benchtop System 4/18/2024

    Walk step-by-step instructions through how you can set up the Nova Benchtop System and make your first LNPs.