RNA Clinical Trials Articles

  1. The Potential Of siRNA To Treat Rare Diseases 8/19/2022

    siRNA is a precision, targeted medicine with the potential to treat many diseases that currently lack effective therapeutic options. In this second article of my series on the subject, I take a closer look at siRNA’s potential for treating rare diseases. 

  2. The Promise Of Gene Silencing: A Primer On siRNA 8/5/2022

    Small interfering RNAs (siRNAs) are short sequences of RNA that interfere with gene expression, reducing or eliminating the expression of a disease-related protein by targeting its corresponding mRNA. siRNAs could treat a wide array of diseases. How does it differ from other therapeutic modalities such as gene therapy and gene editing?

  3. How Can We Move RNA Forward In Our Therapeutics Arsenal? 7/18/2022

    RNA technologies, including mRNA therapeutics, have emerged as a promising drug modality. However, they have unique challenges. BioPhorum has dedicated a team to investigate these challenges and this Q&A shares their practical considerations for how to move this field forward.

  4. Expanding RNA-Based Immune Profiling To Immune State 4/27/2022

    A complete model of the tumor biology is showing promise to become a new standard for predicting patient response and helping more patients benefit from the power of immunotherapy. Expanding RNA-based immune profiling to immune state makes precision medicine more precise.

  5. mRNA Vaccines: Key Considerations For Development & Manufacturing 4/4/2022

    As we wind down National Immunization Awareness Month, this article looks at the complexities around developing and manufacturing mRNA vaccines and how you should address those complexities. Topics include delivery, process validation, long-term effectiveness, GMP, regulatory approval, and more. 

  6. The Current Landscape Of mRNA Vaccines In Clinical Research 3/17/2022

    With the Pfizer-BioNTech and Moderna products, mRNA vaccines made global headlines in 2021 in the fight against COVID-19. As we recognize National Immunization Awareness Month, this article shares how mRNA vaccines currently in clinical research and clinical trials may be soon used to fight HIV-1, herpes, cancer, and more.

  7. RNA's Delivery Challenges 3/16/2022

    Targeted delivery is a major hurdle for effective RNA Therapeutics, a hurdle that must be overcome to broaden the application of clinical translation of cell therapeutics. The mRNA-based therapeutic modality is new to emerging field of immuno-oncology, often referred to as immunotherapy.

  8. What's All The Hype About mRNA Vaccinology? 3/7/2022

    The COVID-19 mRNA-based vaccine success is spurring a further stream of medicines to come. This article provides an overview of mRNA for those who aren't already working in the field, how mRNA is being used in vaccines, and how mRNA can be used for future developments.

  9. The Future Of Influenza Vaccines: Self-Amplifying mRNA 2/4/2022

    As we recognize National Immunization Awareness Month, valued contributor Roberta Duncan of Seqirus looks to the future of vaccine development and the priority that mRNA has become in vaccine research programs. Among other benefits, she says the tech can be moved into clinical trials more rapidly than other platforms.

  10. RNA Takes The Spotlight In The Era Of Precision Medicine 1/4/2022

    RNA are the protein builders, and now that we have the technology to learn more about them, we have better tools for advancing precision medicine.