Featured Articles

31. A Plasmid DNA Purification Process For A Variety Of Therapies 7/5/2022

    Guidance for your plasmid DNA downstream process development, exploring cell harvest, lysis, neutralization and clarification; chromatographic purification; TFF; and sterile filtration unit operations.

32. Frontiers In Digital Bioprocessing: Modular Plant Automation And Cloud 5/26/2022

    As the biopharmaceutical industry is embracing digital transformation and thus evolves in its digital maturity, future-ready concepts will play a leading role in the shift toward bioprocessing 4.0.

33. The Evolution Of AI: Benefits To Biopharma 3/23/2022

    Considering the complexity of bioprocessing and the industry’s inherent “data siloes,” this paper focuses on how companies can use the power of smart data to leverage AI and drive additional insights.

34. Regulatory Guidance On GMP Software 2/23/2022

    Explore the regulatory requirements for software in a biopharmaceutical GxP environment and why software is invaluable for creating an audit trail, reporting, and automating regulatory-related tasks.

35. Multivariate Inter-Stage Batch Profile Monitoring And Future State Estimation 2/3/2022

    How much quicker and easier would it be if we could know the process’s health by looking at a single metric rather than checking hundreds of parameters?

36. Downstream Process For Gene Therapy, Plasmid-DNA Vaccine Development 6/10/2021

    A guide to plasmid DNA downstream process development including clarification, TFF, chromatography, and sterile filtration unit operations.

37. Manufacturing Strategies For mRNA Vaccines And Therapeutics 2/19/2021

    mRNA has emerged as a promising modality offering a great deal of versatility for a wide range of therapeutics and vaccines with its use of non-viral delivery systems.

38. Bio4C ProcessPad™ 21 CFR Part 11 Compliance 1/12/2021

    Learn how Bio4C ProcessPad™ meets 21 CFR Part 11 requirements including unique usernames and passwords, timestamped audit trails, and secure storage of all records.

39. Chromatographic Purification Of Plasmid DNA 11/19/2020

    Widespread application of pDNA in gene therapy is driving increased demand and as a response, plasmid manufacturing must become more efficient with improved productivity. Intensification of chromatographic steps can help address this demand and has led to an exploration of the use of convective media (monoliths, membranes, fibre based technologies).

40. How Pattern Search Finds Anomaly Patterns In Historical Machine Data 10/21/2020

    Owing to the sheer volume of data streaming from sensor profiles, anomalies observed during process monitoring in historical data are extremely difficult to search due to a lack of time series search tools.