FEATURED INSIGHTS

• In Vitro Glycoengineering (IVGE): Taking Control Of Glycosylation

  Discover how to gain precise control over one of the most common and critical forms of protein modification for therapeutic benefit and stability.

• The Evolution Of Nucleotide Production

  From harsh chemicals to gentle enzymes: Explore the groundbreaking shift in nucleotide synthesis, making drug manufacturing cleaner, greener, and more efficient.

• Navigating The Regulatory Landscape For mRNA-Based Therapeutics Post-COVID

  While organizations adapt to evolving safety and efficacy standards for mRNA, collaboration remains essential for navigating challenges like differing regional requirements, higher dosing needs, and analytical complexities.

• Essential Strategies For IVT Optimization

  Optimizing in vitro transcription (IVT) for mRNA is crucial to improving the stability of these molecules and enabling their large-scale production.

• Reducing Risk In mRNA Therapeutic Development

  Advancements in purification, delivery mechanisms, and stability during storage and transport will enable the future of mRNA-based therapies.

• The Future Of mRNA: Four Key Focuses For Industry

  Compared to traditional protein-based therapies, mRNA drugs exhibit unique pharmacokinetic profiles and can be rapidly developed, making overcoming their challenges critical for the industry.

• Optimized Performance Model For Yield And Quality Of The mRNA Product

  Optimize your mRNA production by identifying an optimum set of conditions for the IVT reaction that produces high-quality mRNA in high yield using a design of experiment (DoE) approach.

• Expand Your Toolbox For Quality mRNA Manufacturing

  Explore guidelines for the use of SP6 RNA Polymerase in mRNA synthesis and your mRNA production processes.

• Modulate mRNA Therapy Effectiveness Using Modified Ribonucleotides

  Learn about the problem of immunogenicity of mRNA, modified mRNA via in vitro transcription production, and choosing fit-for-purpose modified ribonucleotides.

• Levers To Optimize The IVT Reaction For Increased mRNA Yield

  Learn about tools to optimize the IVT reaction for enhanced mRNA yield, along with how factors such as magnesium ion and nucleotide concentrations significantly impact that IVT reaction performance.

• Understanding mRNA Technology As A Platform For Biopharma

  Explore the advantages of mRNA technology, the process steps of large-scale mRNA production, and the effect of common contaminants on mRNA manufacturing.