Newsletter | July 29, 2026

07.29.26 -- Why CMC Strategy Will Define The Next Decade Of RNA Therapeutics

FEATURED EDITORIAL

Beyond Cas9: How Diverse Nucleases Are Redefining gRNA Design

As CRISPR technology evolves beyond the original Cas9, gRNAs are transitioning from simple targeting tools to highly engineered, complex molecules. In this Advancing RNA Live, April Sena, Max De Long, and Venkat Krishnamurthy discuss how the rise of diverse nucleases, including prime editors, is impacting gRNA synthesis and purity.

Rethinking The Oligonucleotide Backbone: Why RNA Therapeutics May Need A New Molecular Design Framework

New backbone chemistries could unlock greater control over delivery, specificity, and safety, expanding the molecular design space for RNA medicines.

RNA Therapeutics: Why CMC Strategy Will Define The Next Decade

As RNA matures into an industrial platform, long-term success will depend less on discovery and more on scalable CMC systems, integration, and execution.

INDUSTRY INSIGHTS

6 Trends Redefining Biologics Manufacturing In 2026

Modern bioprocessing relies on smarter fill tech, automation, and data-driven methods. Explore how these shifts lower process risk, boost operational efficiency, and protect high-value products.

Screening T7 Polymerases To Optimize xRNA Yield And Quality

Modern T7 enzyme variants are changing RNA synthesis. Evaluate performance, cost, and supply chain trade-offs to select the right polymerase options for scalable xRNA manufacturing needs.

Science With Purpose: Advancing Sustainability In Biopharma Testing

Learn how biopharma labs are cutting animal use, energy, and paper waste while maintaining GMP compliance — with specific data on 85% labor reductions and 1 ton of CO2e saved annually.

Practical Applications For Controlled And Safe Nucleic Acid Delivery

Explore the science behind LNP formulation development, from ionizable lipids to scalable manufacturing through case studies and screening methods for advancing next-generation therapeutics.

Strategies For Scalable And Cost-Effective mRNA Capping

Industrial mRNA synthesis demands efficiency at scale. Uncover strategic methods for evaluating novel raw materials and refining reaction conditions to maintain yield while cutting costs.

Building Stability Through Integrated Cryopreservation

Early integration of standardized, GMP-aligned cryopreservation improves consistency, documentation, and scalability in advanced therapy programs as they progress toward regulatory submissions.

SOLUTIONS

Address In Vitro Transcription Challenges With RNA Polymerases

mRNA Capabilities And Technology Driving Innovation

Empowering Your Plasmid DNA Workflow