Newsletter | June 3, 2026

06.03.26 -- What's Holding Us Back From Enzymatic siRNA Production?

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Accelerating genomic medicine

Traditional cell therapy manufacturing is hitting a logistical plateau that restricts patient access worldwide. Discover how the concept of the body as a bioreactor could shift the paradigm from external engineering to internal healing. Learn more

FEATURED EDITORIAL

What Is Holding Us Back From Enzymatic siRNA Production Today?

In this Advancing RNA Live clip, CPI’s Claire McCleod shares the biological and logistical hurdles currently keeping full enzymatic production of siRNA at bay. 

Engineering Transient In Vivo CAR-T: Extending Expression, Expanding Access, And Rethinking Immune Reset

In this Q&A, Michael Lam, Ph.D., explores how circular RNA and targeted delivery extend transient CAR expression to enable deep B-cell depletion and controllable immune reset.

Suppressor tRNA Therapeutics: A New Frontier In Treating Genetic Disease

Suppressor tRNAs could unlock a scalable new way to treat genetic diseases caused by nonsense mutations, restoring full-length proteins across multiple indications.

INDUSTRY INSIGHTS

mRNA/saRNA Manufacturing RNA Production & Manufacturing

Discover essential considerations for scaling RNA production to commercial manufacturing. Master the technical processes behind both messenger RNA and self-amplifying RNA.

Regulatory Considerations For Excipients Used In Lipid Nanoparticles

Review the regulatory classification of LNPs, liposomes, and novel excipients. This guide outlines specific global guidance documents and strategic frameworks to overcome compliance challenges.

AI Predictive Maintenance Prevents Batch Loss And Production Shutdown

Wireless vibration sensors protect pharmaceutical manufacturing continuity. See how early equipment issue detection eliminates sudden failures and expensive facility shutdowns.

GLP Compliance In A Modern Lab: What Compliant Actually Requires

GLP compliance isn’t binary. Real defensibility depends on rigorous QA, validated electronic systems, and operational maturity — not just a label.

Improving Self-Amplifying RNA Quality And Potency With IVT Optimization

Examine data on adjusting IVT conditions for self-amplifying RNA. Learn to achieve high yields and low residual dsRNA, ultimately improving the potency of advanced therapeutics.

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The 5th In Vivo Cell Engineering & Gene Editing Summit brings together leading scientists, biopharma innovators, and industry strategists to advance the next generation of in vivo delivery and editing technologies. With growing momentum behind extrahepatic targeting, early clinical readouts, and scalable manufacturing, this meeting offers critical insights to accelerate IND enabling work and shape the future of accessible, durable in vivo therapies. Register now

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