Newsletter | March 26, 2025

03.26.25 -- The mRNA Industry's 3 Big Wishes For CDMOs

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FEATURED EDITORIAL

The mRNA Industry's Three Wishes: Can CDMOs Play The "Genie?"

By AR Welch, Editorial & Community Director, Advancing RNA

During a panel discussion last November, three CDMO execs shared the biggest scientific, regulatory, and technological complexities barring a “magical” solution to each biotech’s wishes. However, as each of the AMM panelists pointed out, there are short- and long-term technological innovations in the works that will be essential in advancing the manufacturing infrastructure for mRNA therapeutics in all their shapes, forms, and scales. 

Must-Have CDMO Capabilities And MSA Make-Or-Breaks For mRNA-LNPs

Three Advancing RNA Live panelists share their greatest needs in outsourcing partnerships for mRNA/RNA-LNP products and where sponsors should be the most prescriptive when drafting an MSA with an outsourcing partner.

INDUSTRY INSIGHTS

Talent Crossover: Extend Your Workforce Through Supplier Partnership

Article | Sartorius

Experts at Sartorius discuss the challenges complex molecules present to drug manufacturers today and the vital role suppliers play in fulfilling talent gaps for their customers.

Effects Of mRNA Capping Technologies

Poster | By C. Cobaugh, et. al., Vernal Biosciences

This study compares two important mRNA capping technologies by evaluating the mRNA integrity, percent Cap1 content, dsRNA content, in vivo expression, and innate immune activation in mice.

CRISPR Clinical Trials And Regulatory Approval Of CRISPR Therapy Drugs

e-book | Synthego Corporation

Navigate the intricate regulatory landscape with knowledge that can help you move your CRISPR therapies quickly and efficiently through clinical trials.

Building Local Biomanufacturing Capacity In South Africa

White Paper | By Jennifer Brant and David Marion, MilliporeSigma

Biovac evolved from a vaccine supplier to a biopharmaceutical innovator, providing a blueprint for expanding Africa's vaccine manufacturing capacity. Gain valuable insights from their journey.

Reducing Risk In mRNA Therapeutic Development

Article | Roche CustomBiotech

Advancements in purification, delivery mechanisms, and stability during storage and transport will enable the future of mRNA-based therapies.

Unlocking The Full Potential Of Genomic Medicine

Article | Cytiva

There are two key challenges to realizing the potential of genomic medicines, but potential technological solutions are on the horizon, and we examine each.

High-Sensitivity IVT mRNA Analysis

Application Note | Agilent Technologies

Quality analysis of in vitro transcribed (IVT) has become an essential part of biotherapeutic workflows. Discover a high-sensitivity kit made for analyzing IVT mRNA quality to advance your research.

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