Newsletter | November 4, 2026

11.04.26 -- The In Vivo CAR-T Boom: Where Does mRNA Fit In?

FEATURED EDITORIAL

Inside The In Vivo CAR-T Boom: Where Does mRNA Fit In?

I had the chance to sit down with ParcelBio’s CEO David Weinberg to learn more about the emerging market dynamics in the in vivo CAR-T space, with a particular focus on the challenges facing RNA biotechs looking to navigate this up-and-coming therapeutic class.

How Should We Measure The True Potency Of RNA Therapeutics?

An RNA therapeutic can generate a strong molecular signal without producing the intended biological function. Let's look at how best to predict whether the RNA has completed its task.

Navigating The Continuum Of LNP Analytical Knowledge

In this clip, Advancing RNA Live speakers Elaine Peters, Philippe Talaga, and Ilya Shestopalov advocate for an orthogonal approach as we strive to better understand our LNP QAs — with particular attention paid to particle size.   

Engineering RNA Agonists For Systemic Immunity Without Systemic Toxicity

Krieg believes the answer lies in a deeper understanding of innate immune biology and the design of RNA/DNA hybrid mimics of viral RNA and DNA that are detected by innate immune receptors.

INDUSTRY INSIGHTS

From LAL To rFC: The Evolution Of Endotoxin Testing

Protect patient safety and ensure regulatory compliance by implementing sensitive, reliable bacterial endotoxin testing as a critical component of pharmaceutical quality assurance.

Defining Cold Chain Strategies For Protecting Product Integrity

Reliable temperature‑controlled storage and monitoring keep sensitive materials stable from fill to patient, protecting quality, preventing degradation, and ensuring safety throughout the cold chain.

A Guide To Enhanced Stability, Delivery, And Efficacy

RNA offers exciting potential for vaccines, gene therapies, and personalized medicine, but challenges related to stability, delivery, and manufacturing persist.

Optimizing Manufacturing Of Lipid Nanoparticles For mRNA Encapsulation

Moving mRNA lipid nanoparticle encapsulation from pre-clinical work to cGMP production is often underestimated. Early process parameter definition and raw material control determine transition risks.

Mapping Cell-Free DNA Manufacturing Precision For mRNA Vaccines

Explore how backbone-free enzymatic DNA templates can improve polyA integrity, long-transcript quality, and RNA yield, with implications for IVT timelines and regulation.

SOLUTIONS

Put Your Oligo Synthesis In Good Hands

Chemicals For mRNA Drug Manufacturing

The Early Advantage For mRNA