Scalability And Sustainability In Mind For Next Generation Primer Support Solid Support

By Ganesh Nawale, Per Denker, Peter Guterstam

Advances in oligonucleotide therapeutics demand synthesis tools that can scale efficiently while maintaining high product quality. Explore how next‑generation primer supports can improve process performance through optimized swelling behavior, higher packing densities, and more predictable flow properties. These characteristics enable larger synthesis scales within the same column volume while stabilizing system pressure and reducing solvent use, key factors for both productivity and sustainability. Data across a range of DNA and RNA lengths demonstrate consistent coupling efficiencies, strong full‑length product percentages, and lower detritylation reagent requirements, helping reduce the risk of depurination and impurity formation.

For teams navigating growing pipelines and tighter operational constraints, these insights offer a clear view into how solid‑support design can influence throughput, cost, and environmental impact.