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| Join Advancing RNA Chief Editor Anna Rose Welch on March 26 at 11 am ET for Advancements in gRNA Manufacturing & Quality. In this discussion with our knowledgeable panelists, we’ll dig into where the biggest gaps remain in our understanding of guide RNA quality and what improvements to the analytical toolbox/manufacturing paradigm need to be made to improve the overall understanding and quality of guide RNA. Register for free today. |
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By Anna Rose Welch, Advancing RNA | In episode 2 of mRNA Hot Takes, the show where we talk about serious RNA things, but with a spicy twist, Advancing RNA's ARW sits down with Sophia Lugo and Michelle Lynn Hall to learn their wish lists for RNA developments for 2026 and their take on an edited quote by Oscar Wilde: “The mRNA industry can survive everything but…?” | |
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Regulatory Considerations For Innovations In Oligonucleotide Supply Chains | By Life Science Connect Editorial Staff | Oligonucleotide therapeutics have rapidly advanced into late-stage and commercial development, shifting regulatory focus toward the maturity of manufacturing and supply chain control rather than therapeutic novelty. Regulatory success now depends on how effectively sponsors translate innovative chemistries into well-characterized, scalable, and sustainable materials and processes. |
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| Developing Robust mRNA Processes In A cGMP Environment | Poster | By Clemens Jakobi, Michal Domański, and Telmo Graça, Lonza | Transitioning to commercial mRNA scales requires rigorous process validation. Explore emerging technologies and strategies to optimize manufacturing within a strictly regulated environment. |
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| Levers To Optimize The IVT Reaction For Increased mRNA Yield | Application Note | By A. Latta, N. Sammeta, S. Kutter, et al., Roche CustomBiotech | Mastering IVT yield requires balancing magnesium and nucleotide ratios. Learn how specific buffers and pyrophosphatase optimize mRNA synthesis for scalable, high-quality therapeutic production. |
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| The Hidden Secrets Of AEX Oligonucleotide Analysis | Article | KNAUER | Fine-tuning pH and ionic strength is essential for identifying truncated sequences. Discover how to transform complex purification challenges into reproducible data for reliable oligo analysis. |
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