Newsletter | September 17, 2025

09.17.25 -- Oligos Step Into The Spotlight: A Growing Force In Genetic Medicine

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As additional mRNA therapeutics makers progress toward and into the clinic, we're gathering more knowledge about what makes our mRNA products "tick," and how our processes impact the overall quality of our products. Join this expert panel for a timely discussion in the mRNA therapeutics space. Registration is free thanks to the support of Millipore Sigma.

FEATURED EDITORIAL

The Price Is… Almost Right: mRNA Edition! COGS Reduction Strategies

The following article will outline the current state of COGS in the mRNA industry. But heaven forbid this be your normal conference panel write-up. No, below I share one expert’s insights in the form of a never-before released episode of The Price is Right…or perhaps more fittingly: The Price is…Sort Of, Almost, Not Quite Right! 

Oligos Step Into The Spotlight: A Growing Force In Genetic Medicine

Oligonucleotide therapeutics are experiencing a new wave of momentum. As the science evolves and the market opportunity expands, the landscape is poised for continued growth and diversification.

INDUSTRY INSIGHTS

Digital Twins And Mechanistic Models For Optimized Bioprocessing

Integrating AI and having a robust IT infrastructure is crucial for modernizing your processes. Discover how digital twins and mechanistic modeling are revolutionizing biomanufacturing, enhancing efficiency, and reducing costs.

Essential Strategies For IVT Optimization

Optimizing in vitro transcription (IVT) for mRNA is crucial to improving the stability of these molecules and enabling their large-scale production.

Quality Concepts In IVT mRNA Development, Manufacturing, And Analytics

Stay ahead in mRNA therapeutic development by mastering the essential quality systems, process controls, and analytical methods required for robust GMP production and efficient manufacturing.

RNA's Higher-Order Structure Dynamics For CRISPR Applications

Scientists are gaining valuable knowledge about the structural dynamics of guide RNAs used in CRISPR-Cas9. This deeper understanding could pave the way for improved gene editing tools.

TFF Of LNPs Results In 10X Concentration Within 20 Minutes

Dive into a study that details how a single-pass tangential flow filtration system can achieve a tenfold concentration of liposomal nanoparticles in under 20 minutes.

LBA Vs. LC-MS: Competing Technologies At A Development Crossroad

Watch as bioanalytical experts Shane Karnik, MS, and Matt Hartle, Ph.D., explore why many sponsors are reevaluating the use of LBA for large molecule protein analysis in favor of LC-MS.

Replicate Bioscience And Cytiva Collaborate To Deliver srRNA-LNP Vaccines

Discover how self-replicating RNA (srRNA) can revolutionize vaccine development with sustained protein expression, lower doses, and fewer side effects to advance next-gen RNA therapeutics.

Improving Toxicology Testing For Inhalation Products

By embracing new approach methods, regulatory agencies can revolutionize toxicology testing. These methods can be adapted for various medications, including inhalers and nasal-administered drugs.

De-Risk mRNA Regulatory Approvals

Gain insight into how you can de-risk mRNA regulatory approvals with critical quality attribute characterization and lot release testing.

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Biologics US 2025: Bringing Biopharma Breakthroughs to life

Join us, as Biologics US 2025 gathers North America’s biopharma leaders to tackle challenges in antibody and ADC R&D. See how experts are using AI-assisted design, novel protein targets, and advanced conjugation strategies to drive effective therapeutics. Don’t miss keynotes from Steve Turner and Ray Deshaies, GLIMPSE-1 human-first antibody insights from Wyatt McDonnell, and our Innovations & Breakthroughs Under the Stars Garden Party. Claim your free ticket.

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