Newsletter | May 27, 2026

05.27.26 -- Modernizing Oligonucleotide Synthesis

SPONSOR

The 6th mRNA-Based Therapeutics Summit returns to Boston as the leading forum accelerating mRNA discoveries into scalable, clinically validated therapies. Amid rapid deal making and progress across in vivo CAR T, gene editing, and cancer immunotherapy, 300+ leaders from pharma, biotech, and regulators unite. With three scientific tracks plus new AI driven design and next gen delivery focus days, this flagship event drives innovation, partnerships, and pipeline acceleration.

FEATURED EDITORIAL

Beyond The Gold Standard(s): Modernizing Oligonucleotide Synthesis

A few weeks ago, I had the chance to sit down with OPT Congress speaker Phil Baran, Richard Lerner Chair Professor, Department of Chemistry, Scripps Research. Baran was slated to (and did) present a keynote on the innovations shaping the next generation of oligo synthesis. Here, I share the biggest takeaways I had from our conversation, touching on how he sees the science of oligo chemistry and manufacturing advancing in the near and far future. 

RNA Manufacturing In 2045: Will SPOS Still Have A Seat At The Table?

What does the future hold for siRNA manufacturing? Here, Advancing RNA Live panelists Claire MacCleod and Jill Caswell share their visions on what the future holds for solid-phase synthesis, chemoenzymatic ligation, and fully enzymatic oligo synthesis. 

Engineering Repeat-Dose RNA: Engineering Around Immune Recognition In Repeat-Dose RNA Therapeutics

Designing repeat-dose RNA means engineering around immune recognition — optimizing payloads, purity, and delivery early to sustain efficacy, tolerability, and durability across multiple administrations.

INDUSTRY INSIGHTS

Annex 1: Sterile Fill/Finish For Early Phase Clinical Supplies

Complying with Annex 1 requirements hinges on advanced isolator technology and rigorous integrity testing. Implement these essential contamination control strategies to ensure patient safety.

Mastering Quality Systems And Analytical Methods For GMP mRNA Lines

Stay ahead in mRNA therapeutic development by mastering the quality systems, process controls, and analytical methods required for robust GMP production and efficient manufacturing.

Validation Of mRNA Concentration Determination

mRNA-based therapeutics require comprehensive analytical testing to meet regulatory requirements. Optimize processes and ensure fast and reliable results as you bring your product to market.

mRNA Vaccines And Therapeutics: Current Trends And Perspectives

Delve into the advancements and transformative impact of mRNA vaccine technology on modern medicine and explore how this technology is revolutionizing healthcare for the future and beyond.

Establishing Analytical Methods For mRNA-Based Therapies

Developing safe, effective mRNA therapies requires robust characterization. Review detailed assay descriptions for sequence identification and lipid nanoparticle composition monitoring.

A New Center For Continuous mRNA Manufacturing

Explore how a partnership between academia, regulatory agencies, and manufacturing organizations has the potential to reshape the way we produce and distribute mRNA-based therapies.

SOLUTIONS

Speed, Precision, Impact: The CRO Revolutionizing Bioanalysis

mRNA/LNP Development And Manufacturing Services

Systems For Lipid Nanoparticle (LNP) Production

A Next-Gen Polymerase For Self-Amplifying mRNA