Newsletter | January 28, 2026

01.28.26 -- Manufacturing Complexities Stymie In Vivo Progress

SPONSOR

Webinar: The mRNA Journey: From Design to LNP-Ready Molecules for Research

Discover an optimized end-to-end workflow for producing high-quality IVT mRNA for research applications. This Agilent webinar covers every step—from sequence design and PCR-based DNA template preparation to transcription, lipid nanoparticle formulation, and QC testing with Agilent TapeStation and Fragment Analyzer systems—enabling fast, reliable, small-scale mRNA production for non-clinical research such as vaccines, protein expression, and gene or cell therapy. Watch it here.

FEATURED EDITORIAL

Strained Manufacturing, Complexity Stymie In Vivo Progress

 Explicitly mapping delivery challenges to the associated GMP process steps converts biological risk into operational risk.

Making Personalized Cancer Vaccines Reality: The Manufacturing Challenge Ahead

Personalized cancer vaccines are becoming feasible, but scaling fast, affordable, data-driven manufacturing is the central challenge to bringing these individualized therapies to more patients.

Strategies To De-Risk Next-Gen mRNA Raw Materials

In this Advancing RNA Live clip, Khaled Yamout and Sanofi’s Francoise Ribes share the quality considerations that are top of mind when evaluating a novel raw material, as well as how the broader industry (i.e., standard setting organizations, suppliers, and biotechs) can arrive at a clearer understanding of a material’s quality.

INDUSTRY INSIGHTS

ESMO Congress 2025: Highlights From Berlin

Turn the insights from 2025’s ESMO into action by partnering to accelerate innovation through smarter trial design, stronger biomarker planning, and truly global collaboration.

Analyzing Poly(A) Tails Of In Vitro Transcribed RNA

Find out how to achieve reliable IVT mRNA quality. Learn the best practices for precise analysis, including proper sample prep and system optimization for high-resolution results.

Harnessing Chemistry For Scalable Lipid Manufacturing

Discover how scalable lipid nanoparticle (LNP) technology is revolutionizing mRNA-based therapies and shaping the future of treatment innovation.

A Guide To Optimize mRNA With Enhanced Stability, Delivery, And Efficacy

RNA offers exciting potential for vaccines, gene therapies, and personalized medicine, but challenges related to stability, delivery, and manufacturing still persist.

Screening T7 Polymerases To Optimize xRNA Yield And Quality

Understand how the evolution of T7 polymerase is optimizing in vitro transcription for RNA therapeutics, and how to balance performance, cost, and supply to make smart choices for your xRNA manufacturing.

Efficient, Scalable Purification Of mRNA By Affinity Chromatography

Increasing demand for mRNA as a therapeutic product requires efficient, scalable purification methods. Here, a monolithic stationary phase is used to purify mRNA from a capping mix of Luc2 RNA.

Improve Nanoparticle Formulation And Drug Delivery With These Solutions

Watch how revolutionary and environmentally sustainable nanoparticle technologies coupled with innovative formulation approaches can address drug solubility issues and add value for patients.

SPONSOR

BioPlan Associates is conducting its 23rd Annual Global Biopharmaceutical Manufacturing and Trends Analysis and needs your insights for the biopharma industry’s most comprehensive global benchmarking analysis! For over 20 years, BioPlan Associates has analyzed advances in bioprocessing, new technologies, and emerging trends, supported by global institutional and media partners. For all completed, qualified surveys, they'll offer an Amazon e-gift card, a copy of the summary results, and the 2026 Top Trends in Biomanufacturing White Paper.

SOLUTIONS

Solutions For mRNA-LNP Vaccine Production And Analysis

De-Risk mRNA Regulatory Approvals

Cap AU Kit: Next-Gen Polymerase For Self-Amplifying mRNA

Services For Regulatory Confidence And Manufacturing Excellence