Newsletter | April 8, 2026

04.08.26 -- Fact Checking The "Death" Of The US mRNA Industry

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Personalized cancer vaccines are pushing immuno-oncology forward, but delivery and manufacturing hurdles still stand in the way. In this webinar, Cytiva explores how optimized ionizable LNPs can improve mRNA vaccine delivery, tolerability, and tumor response, while supporting small-scale clinical manufacturing strategies that help move PCV candidates from concept to clinic with greater confidence. Click here to learn more.

FEATURED EDITORIAL

Engineering Translation: How tRNA Therapeutics Expand The RNA Toolkit

Engineered tRNAs target translation itself — correcting shared errors like premature stop codons at the ribosome — to restore functional protein and redefine precision medicine by mechanism, not diagnosis.

Proteomics Tools: A Resurrection

For decades, the evolution of proteomics has lagged. Now, a resurrection is underway. New tools are dismantling limitations, signifying a maturation of systems biology.

The Future Of Kidney Disease Therapeutics: Nanomedicine In Nephrology

Nanomedicines are solving the drug delivery problem in kidney disease. The next step: bridging the translational gap to advance these technologies into the clinic.

Carolina Reapers: Fact-Checking The "Death" Of The US mRNA Industry

In our mRNA Hot Takes "Season Finale," Advancing RNA's ARW sits down with Radar Therapeutics' Sophia Lugo and Entrée Bio's Michelle Lynn Hall to answer yet another loaded question: Are things in the U.S. for mRNA as bad as they truly seem?

INDUSTRY INSIGHTS

How To Bring Your LNP Formulation To Clinical/Commercial Manufacturing

Learn the critical parameters for selecting lipid excipients and the essential process development steps required to transition your LNP formulations into successful human clinical trials.

Optimizing In-Vitro Transcription For High-Potency Self-Amplifying RNA

Discover how refined IVT conditions yield higher RNA outputs with lower residual dsRNA. This study explores methods to enhance the potency and purity of next-generation therapies.

mRNA Therapeutic Development Through Enhanced IVT Capping Efficiency

High-performance synthetic mRNA requires precise enzymatic control. See how advanced RNA polymerase technology improves capping efficiency to support the production of more robust therapies.

Implementing Robust And Cost-Effective mRNA Capping Strategies

Master the strategies for economical mRNA capping without sacrificing quality. This guide details how to evaluate new materials and optimize synthesis workflows for maximum facility yield.

De-Risking The Transition From Preclinical To cGMP mRNA Manufacturing

Ensure your mRNA construct is future-proof by following specific development steps designed for cGMP compliance. Explore how to optimize early-stage designs to avoid costly late-stage errors.

SOLUTIONS

Capacity Update: Analytical Services

Put Your Oligo Synthesis In Good Hands

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With 1900+ attendees, TIDES USA, May 11-14, 2026, at Boston's Hynes Convention Center, is North America's leading forum for advancing oligonucleotide, peptide, mRNA, genome editing, and delivery innovations. This event bridges research to reality, fostering collaboration, and breakthrough solutions. Explore cutting-edge workshops, tracks, and exhibits while connecting with global pioneers like Robert Langer and Kiran Musunuru. Register early for any early bird savings and save an additional 10% with VIP code ADVRNA10 at checkout!