Newsletter | September 23, 2026

09.23.26 -- Evolutions in mRNA Drug Product Analytical Development

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Evaluating The Decisions That Shape mRNA Success | 09.30.26

This session explores the critical decisions that drive successful mRNA therapy and vaccine development. Attendees will gain practical insights into challenges related to manufacturing, raw materials, formulation, supply chains, and regulatory expectations. The discussion will highlight strategies for optimizing mRNA design, process development, facility planning, and production workflows to build robust, scalable, and well-characterized manufacturing programs. Learn more.

FEATURED EDITORIAL

Evolutions In mRNA Drug Product Analytical Development

How well do we know our mRNA-LNP drug products today? In this discussion, Advancing RNA panelists unpack what we continue to learn about the analytical methods we have at our disposal today, while identifying which attributes we should be paying closer attention to today.

Beyond Protein Targets: Why The Regulatory Genome Could Redefine RNA Medicine (Pt. 1)

Explore how the regulatory genome and lncRNAs are shifting RNA medicine beyond protein targets, enabling cell-state reprogramming to treat disease at its source.

Reprogramming The Tumor Microenvironment: Why RNA Immunotherapy Is Targeting Liver Metastases (Pt. 1)

RNA/DNA immunotherapy may overcome liver metastases by reprogramming innate immunity, restoring interferon signaling, and improving responses to checkpoint inhibitors.

Bridging The Atlantic: A European Executive's Guide To Building A Successful U.S. RNA Business (Pt. 2)

European RNA biotech leaders can accelerate U.S. success by aligning fundraising, partnerships, manufacturing, hiring, and regulatory strategy from day one.

The Preclinical Gauntlet: Securing Capital And Designing Regulatory Pathways For Ultra-Rare ASO Drugs (Pt. 2)

SynaptixBio CEO Dan Williams explains why funding, regulatory strategy, toxicology, and disciplined execution — not just science — determine success in advancing ultra-rare ASO therapies.

INDUSTRY INSIGHTS

Enabling Effective Passive And Active Immune Cell Targeting Strategies

Targeted LNPs that bypass the liver and home to the spleen could reshape in vivo CAR T cell manufacturing. See the data behind the approach.

dsRNA: Why Polymerase Choice Matters

Polymerase selection during IVT shapes dsRNA levels, processing costs, and product quality. See how enzyme engineering reduces abortive transcripts and improves purity profiles for complex mRNA manufacturing applications.

Screening T7 Polymerases To Optimize xRNA Yield And Quality

Discover how the evolution of T7 polymerase is optimizing in vitro transcription for RNA therapeutics. Learn to balance performance, cost, and supply to make smart choices for your xRNA manufacturing.

Charged For Action: The Hidden Secrets Of AEX Oligonucleotide Analysis

Understanding how to fine-tune pH and ionic strength allows for the detection of truncated sequences and single-nucleotide variants, turning complex purification challenges into reproducible data.

Supporting Complex Manufacturing For Liquid And Lyophilized Drugs

Aseptic fill and finish operations gain efficiency and precision with modular isolator technology, inline weight checks, and lyophilization, which are ideal for mRNA-LNPs and other sensitive modalities.

Characterizing mRNA Using Ion-Pairing Reversed-Phase LC/MS

mRNA poly(A) tail analysis depends on targeted digestion, clean LC/MS conditions, and reliable deconvolution. See how RNase 4 digestion and optimized ion-pairing support reproducible results.

How To Bring (Any) mRNA To Life: Simplifying Nucleic Acid Encapsulation

New technologies for the encapsulation of nucleic acids, such as FDmiX, can potentially overcome limitations of currently available standard mixing technologies.

SOLUTIONS

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A Next-Gen Polymerase For Self-Amplifying mRNA

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