Newsletter | April 23, 2025

04.23.25 -- Establishing Analytical Methods For mRNA-Based Therapies

FEATURED EDITORIAL

Implement Creative And Collaborative Strategies To Optimize Your mRNA Development And Manufacture

No matter how you approach it, mRNA manufacturing is expensive. The raw materials, technologies, and educated labor force require immense investment. To avoid incurring extra costs and to ensure your strategy is precise and risk averse, identify an experienced partner that prioritizes communication and first-time-right manufacturing.

Fermentation, Analytics, & Quality: Plasmid Production Advancements & Challenges For mRNA Development

Advancing RNA Live panelists Tyler Goodwin and April Sena start off our latest discussion on technology innovations in mRNA production by surveying the current manufacturing process for plasmid production, highlighting where they’ve seen advancements and what biotechs need to consider to obtain plasmids of the appropriate quality for mRNA production.

What Happens If The National Cancer Institute Loses Funding?

The National Cancer Institute is operating under a continuing resolution that maintains funding at the FY 2024 level of $7.22 billion. But when adjusted for inflation, it effectively reduces the real value of research dollars. So what are the consequences?

INDUSTRY INSIGHTS

Establishing Analytical Methods For mRNA-Based Therapies

Here, we provide a detailed description of assays for sequence identification and LNP composition in mRNA-LNP products that support the development of safe and effective mRNA therapies.

The Power Couple: CRISPR And Oligonucleotides

Drug design using CRISPR depends on long guide RNA (gRNA) sequences. Find out how this match between long oligos and CRISPR works.

Customized mRNA Processing For Improved Development, Manufacturing

Optimize mRNA development by learning key strategies for process refinement, critical component identification, and in-process analytics to enhance therapeutic production.

Development Of LNP Formulations Using The KNAUER NanoScaler

Lipid nanoparticles (LNPs) offer a robust solution for nucleic acids. The NanoScaler system optimizes this technology, enabling scalable and reproducible LNP formulations for diverse applications.

The Future Of mRNA: Four Key Focuses For Industry

Compared to traditional protein-based therapies, mRNA drugs exhibit unique pharmacokinetic profiles and can be rapidly developed, making overcoming their challenges critical for the industry.

Optimizing siRNA Therapeutics: Addressing Manufacturing Complexities

Discover key strategies to optimize siRNA therapeutics by addressing critical nonclinical and manufacturing challenges for a smoother path to commercialization.

How Nanoparticle Platforms Are Unlocking The Potential Of Genetic Medicine

Discover how this innovative platform accelerates gene therapy delivery by screening polymeric nanoparticles, enhancing precision, efficiency, and regulatory pathways for genetic medicines.

SPONSOR

TIDES USA 2025

How are industry pioneers accelerating the next wave of therapeutic breakthroughs? Find out at TIDES USA 2025—USA's premier forum for oligonucleotide, peptide, mRNA, genome editing, and drug delivery innovations. May 19-22, 2025 @ Manchester Grand Hyatt San Diego; 150+ expert speakers; 5 tracks & 8 workshops; 1,900+ attendees with networking opportunities; Advanced technology showcases. Save 10% with VERTMARKETS at Checkout.