Newsletter | August 27, 2025

08.27.25 -- Beyond Solid-Phase Synthesis: The Momentum Of Oligo Manufacturing

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As additional mRNA therapeutics makers progress toward and into the clinic, we're gathering more knowledge about what makes our mRNA products "tick," and how our processes impact the overall quality of our products. Join this expert panel for a timely discussion in the mRNA therapeutics space. Registration is free thanks to the support of Millipore Sigma.

FEATURED EDITORIAL

Beyond Solid-Phase Synthesis: The Momentum Of Oligonucleotide Manufacturing

Overall, there were three main takeaways I gleaned from our conversation that suggest the oligo sector, though more established than its mRNA cousin, is not comfortable with the status quo and is actively trying to grow beyond the limits of its current manufacturing paradigm. Here in part 1, we’ll start with my number one takeaway, which also comes equipped with a bit of history as to how we find ourselves at our current juncture.

Inside Arbor Biotech's In Vivo Gene Therapy Approach

Following recent news about first-in-human testing, two executives discuss the science and manufacturing strategy for the company's lead candidate, ABO-101.

Breaking New Ground: MHRA Embraces A Future With Patient-Specific mRNA

In this Advancing RNA clip, panelists Ulrike Jägle and Tiffany Lucas unpack the benefits they see to the MHRA's new guidance on mRNA cancer immunotherapies, including the agency’s support for bioinformatics approaches and its burgeoning framework for developing and justifying a truly personalized medicine.

INDUSTRY INSIGHTS

Perspectives And Projections On The 2025 Biotech Landscape

Listen to Aditya Kotta discuss key biotech trends, from post-COVID market shifts to global R&D and investment strategies, as well as China’s rising role in pharmaceutical innovation.

Downstream Processing's Role In RNA-LNP Drug Development Optimization

Explore the key aspects of lipid nanoparticle (LNP) development, including the essential downstream processes of Tangential Flow Filtration (TFF) and normal flow filtration.

Structural Characterization Of RNA And Detection Of RNA-Ligand Binding

Delve into the intricacies of riboswitch behavior and ligand interactions and gain valuable insights into gene regulation and potential therapeutic targets.

Building Local Biomanufacturing Capacity In South Africa

Biovac evolved from a vaccine supplier to a biopharmaceutical innovator, providing a blueprint for expanding Africa's vaccine manufacturing capacity. Gain valuable insights from their journey.

Improving Toxicology Testing For Inhalation Products

By embracing new approach methods, regulatory agencies can revolutionize toxicology testing. These methods can be adapted for various medications, including inhalers and nasal-administered drugs.

Nanomedicine Modalities Find Path To Clinic Through Analytics

Lipid nanoparticles have revolutionized drug delivery, ushering in a new era of nanomedicine. Discover how advanced analytical tools are accelerating next-generation LNP therapeutics.

High-Sensitivity IVT mRNA Analysis

Quality analysis of in vitro transcribed (IVT) has become an essential part of biotherapeutic workflows. Discover a high-sensitivity kit made for analyzing IVT mRNA quality to advance your research.

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Secure your spot for AMM ASCENT, September 16 - 18! Join senior executives and top decision-makers for timely discussions, from What’s Next After Baby KJ? The Future of mRNA in Gene Editing and Rare Disease, to Innovation in mRNA Cancer Immunotherapies, to Global Industry Outlook. You won’t want to miss this event. Review the speaker lineup, agenda, and book your stay!