03.25.26 -- Benchmarking RNA Delivery Performance: Toward Standardized Metrics For Translational Success

Join Advancing RNA Chief Editor Anna Rose Welch on March 26 at 11 am ET for Advancements in gRNA Manufacturing & Quality. In this discussion with our knowledgeable panelists, we’ll dig into where the biggest gaps remain in our understanding of guide RNA quality and what improvements to the analytical toolbox/manufacturing paradigm need to be made to improve the overall understanding and quality of guide RNA. Register for free today.

As RNA pipelines mature, delivery success demands shared benchmarks. This article proposes standardized, stage-specific metrics to compare platforms, guide optimization, and build regulatory confidence.

Why do LNPs that look identical behave differently in cells? This piece reveals how mixing physics and payload uniformity shape RNA potency, safety, dosing, and manufacturability—beyond size alone.

In this opening Advancing RNA Live clip, NanoVation Therapeutics’ Dominik Witzigmann and Stealth Co’s John Zuris share the scientific advancements they’ve been watching most keenly in the LNP space, as well as some of the evolutions they’re seeing in the overall quality of our RNA-LNP products.

The Alliance for mRNA Medicines and US Pharmacopeia invites you to attend a two-day workshop, End-to-End Analytical Solutions for mRNA Therapeutics: Supporting Manufacturing and CMC Needs, on April 14-15. Join leading scientists and regulatory stakeholders to explore critical aspects of Chemistry, Manufacturing, and Controls for mRNA-based products, with sessions featuring cutting-edge analytical methods, platform technologies, and emerging applications. Register here to attend in-person or virtually.