Newsletter | May 2, 2026

05.02.26 -- Advancing RNA Newsletter Best Of April

APRIL'S BEST FEATURED EDITORIAL

Carolina Reapers: Fact-Checking The "Death" Of The US mRNA Industry

Welcome to Advancing RNA’s mRNA Hot Takes for our "Season Finale." Advancing RNA's ARW sits down with Radar Therapeutics' Sophia Lugo and Entrée Bio's Michelle Lynn Hall to answer yet another loaded question: Are things in the U.S. for mRNA as bad as they truly seem?

The Monster Under The Bed: Defining Potency In The mRNA Space

How are we defining and measuring our product’s potency? This question, posed at a past CASSS mRNA Symposium, is far from straightforward, and, dear reader, based on the resulting discussion amongst regulators and panel members, it became clear we have a lot of different definitions of what potency even is in the mRNA space.

The Evolving CMC Landscape For mRNA-LNPs

In this Advancing RNA Live clip, CMC consultant Sujit Jain unpacks the levels of maturity he’s observed in process and analytical development, as well as supply chain. While vaccines and liver-targeting therapeutics boast what we can call a reproducible platform today, targeted LNP therapies introduce a handful of scale-up sensitivities and characterization hurdles.

APRIL'S BEST INDUSTRY INSIGHTS

Optimizing In-Vitro Transcription For High-Potency Self-Amplifying RNA

Discover how refined IVT conditions yield higher RNA outputs with lower residual dsRNA. This study explores methods to enhance the potency and purity of next-generation therapies.

Why ddPCR Is Becoming The Standard For Gene Therapy Biodistribution

Precision is critical in gene therapy. Learn why this digital quantification method is becoming the standard for reliable, defensible data across various tissues and clinical study phases.

De-Risking The Transition From Preclinical To cGMP mRNA Manufacturing

Ensure your mRNA construct is future-proof by following specific development steps designed for cGMP compliance. Explore how to optimize early-stage designs to avoid costly late-stage errors.

APRIL'S BEST SOLUTIONS

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