Newsletter | June 17, 2026

06.17.26 -- Why Chemoenzymatic Ligation Is Non-Negotiable In siRNA Manufacturing

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Accelerating genomic medicine

Traditional cell therapy manufacturing is hitting a logistical plateau that restricts patient access worldwide. Discover how the concept of the body as a bioreactor could shift the paradigm from external engineering to internal healing. Learn more

FEATURED EDITORIAL

The Cell-Free Revolution: Breaking The Plasmid DNA Bottleneck

I was excited to be given the opportunity to sit down with Jodi Barrientos, CEO, Ribbon Bio, to learn more about the current state of the synthetic DNA space. In the following Q&A, Barrientos and I discuss some of the synthetic DNA industry’s biggest goals and the challenges that stand in the way of bringing synthetic plasmids more commonly into the mRNA development paradigm. 

Why Chemoenzymatic Ligation Is A Non-Negotiable Step For Future siRNA Production

Is the future of RNA manufacturing fully enzymatic? In this Advancing RNA Live clip, panelists Claire McCleod and Jill Caswell unpack why the "hybrid" chemoenzymatic approach is an essential bridge to an enzymatic future for siRNA production. 

Beyond Guanidine: Scientists Discover A Mysterious Riboswitch Variant With A Different Biological Target

Scientists identified a mysterious riboswitch variant that resembles guanidine sensors but likely evolved to detect an entirely different metabolite.

Engineering RNA Payload Distribution In LNPs To Unlock Higher In Vivo Gene Editing Efficiency

New research shows RNA payload distribution inside LNPs — not just encapsulation efficiency — may be key to unlocking stronger in vivo gene editing performance.

INDUSTRY INSIGHTS

How To Bring (Any) mRNA To Life: Simplifying Nucleic Acid Encapsulation

New technologies for the encapsulation of nucleic acids can potentially overcome current limitations of standard mixing methods, offering researchers a more reliable path to production.

Effective Strategies To Minimize Product Loss During Fill Finish

Every drop of high-value biologic lost in fill finish is money left on the table. Explore practical, actionable strategies to safeguard your yield and improve final manufacturing outcomes.

Reducing Risk In mRNA Therapeutic Development

Advancements in purification, delivery mechanisms, and stability during storage and transport are driving the future of mRNA-based therapies by reducing systemic manufacturing risks.

Optimizing Oligonucleotide Synthesis Workflows For Scale Up

Discover how early choices in oligo synthesis workflows shape performance. Learn what to consider across design, reagents, and system optimization to build a process ready for smooth scale‑up.

How Specialized CMC Platforms Accelerate mRNA Clinical Timelines

Developing a client-sponsored Target Product Profile (TPP) and Analytical Target Profile (ATP) is critical to move your drug product to clinic efficiently and meet acceptance criteria.

Establishing Reliable Analytical Methods For mRNA Based Therapies

Review detailed descriptions of assays for sequence identification and LNP composition. These insights support the development of safe, stable, and highly effective mRNA-LNP products.

Why Anion Exchange Chromatography Excels In Large Scale Purity

Read how anion exchange chromatography delivers high loading capacity and clinical-grade purity while addressing common scale-up challenges like aggregation and equipment longevity.

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