Newsletter | July 16, 2025

07.16.25 -- What Picasso Can Teach The mRNA Industry

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Webinar: Sustainable vaccine manufacturing: securing the future of global health

Join Cytiva for a webinar on the future of vaccine manufacturing, highlighting next-gen technologies, mRNA platforms, and digital tools that boost efficiency, cut costs, and expand access. Learn practical strategies to optimize processes, streamline tech transfer, and enable distributed manufacturing—equipping you to build more resilient, flexible, and sustainable production systems. Click here to learn more.

FEATURED EDITORIAL

Pictures At An [mRNA]Exhibition: What We Can Learn From Picasso (Pt. 1)

In my presentation, I argued that there are several lessons we can learn from Picasso that will also help our own industry mature. In the upcoming weeks, I plan to unpack these lessons, highlighting specific instances in which I see our industry taking these lessons to heart and making progress — starting here with lesson 1: Being Innovative Comes After We Master The Basics

Navigating FDA Regulatory Changes: Policy Shifts, Deregulation, Restructuring, And Future Oversight

Recent shifts within the U.S. FDA reflect an increasingly complex tension between scientific rigor and accelerating political and economic pressures. Here are the newest developments and emerging focal points.

Proactive Partnerships: Engaging FDA And EMA During mRNA Process Development

Panelists Tiffany Lucas and Ulrike Jägle address an audience question about when and how to approach the regulatory agencies for mRNA process development. In addition to listing the different FDA and EMA meeting opportunities available to sponsors, Jägle reminds us of one critical best practices sponsors shouldn’t forget when approaching the agencies.

INDUSTRY INSIGHTS

Overcome The Hidden Complexities Of mRNA Process Development

Discover the complexities underlying the perceived simplicity of mRNA process development, as well as characterization strategies and models for predicting process outcomes at early stages.

Exploring RNA Structure And Ligand Interactions With MMS

Learn about using microfluidic modulation spectroscopy (MMS) to probe RNA base pair and ligand interactions in solution. This research explores the effects of lipid adducts on RNA structure and characterizes base pairing with MMS.

Efficient mRNA Purification Using Anion Exchange Chromatography

Explore how anion exchange chromatography with dual gradient elution enables efficient mRNA purification at ambient temperature.

Bridging Advanced Manufacturing, Pharma 4.0, And RNA Therapeutics

Pharma 4.0 and RNA therapeutics are transforming drug manufacturing. Discover how digital tools, real-time monitoring, and scalable platforms are enhancing quality and efficiency in this evolving landscape.

How To Successfully Control The Upscaling Of Your LNP Formulation

Discover key strategies for controlling LNP formulation and upscaling. Explore the science behind lipid nanoparticles, critical parameters, and achieving effective turbulent mixing for optimal outcomes.

How AI Can Accelerate Clinical Research And Outbreak Response

AI-driven automation and organ-on-a-chip technology can be leveraged to accelerate infectious disease research, enhance assay efficiency, and improve therapeutic development for global health threats.

Insights And Strategies For GMP Manufacturing Of RNA-Lipid Nanoparticles

The emergence of RNA-encapsulated-lipid nanoparticles has introduced a seismic shift in biopharma innovation. But how will the industry adapt to diversifying applications and scales going forward?

Advanced Isolator Tech Boosts Manufacturing Efficiency And Quality

Isolator technology can run continuously over several days, minimizing operator interaction and other opportunities to introduce contamination — ideal for high-volume, time-limited production runs.

A New Centre For Continuous mRNA Manufacturing

Explore how a partnership between academia, regulatory agencies, and manufacturing organizations has the potential to reshape the way we produce and distribute mRNA-based therapies.