Transfection Solutions For Highly Reliable And Effective Gene Silencing With siRNA And Co.

RNAi refers to the phenomenon of  RNA interference and was first discovered in 1990 where scientists observed that particular RNA strands had the ability to suppress gene expression in plant. More specifically, RNAi mechanism sees these small pieces of RNA block post-transcriptional translation and thus silencing protein production for particular genes/sets of genes. This is a completely natural process in normal cell regulation but opens up vast opportunities for gene therapy applications for the treatment or management of genetic disorders such as cancer or muscular dystrophy for example. Of course, any gene therapy is only as good as it’s delivery system, hence in this article we shall discuss the process of transfection and highlight two highly effective vectors for both in vitro and in vivo gene therapy applications.