Newsletter | August 28, 2024

08.28.24 -- The RNA Challenge Keeping RNA Execs Up At Night

FEATURED EDITORIAL

Translatability: The Challenge Keeping mRNA Execs Up At Night

It goes without saying that there’s a lot we need to understand about what impacts our drug products’ potency and safety. But I also appreciated the panels’ focus on the importance of gaining a clearer understanding of the biological factors that influence the strength, durability, immunogenicity, and overall deliverability of our RNA therapeutics in vivo.

End-To-End mRNA DS And DP Manufacturing Processes

This article demystifies the manufacture of mRNA encapsulated in lipid nanoparticles across unit operations for plasmid linearization, drug substance (DS) manufacture, and drug product (DP) manufacture.

In Vivo Genetic Medicines Need a Guide: The Answer Lies in Harnessing the Transcriptome

This article by Radar Therapeutics explains why the DNA/RNA revolution is underway and why solving specific targeting is next.

INDUSTRY INSIGHTS

The Power Couple: CRISPR And Oligonucelotides

Drug design using CRISPR depends on long guide RNA (gRNA) sequences. Find out how this love match between long oligos and CRISPR works.

Process Validation: A Critical Step In A Biopharma Product's Lifecycle

Process validation is a critical step in the successful commercialization of a new biopharmaceutical. Learn about the challenges and the importance of applying it throughout the entire product lifecycle.

Empowering A New Era Of Patient-Centric Medicines

Discover the challenges pharma companies are facing as they switch focus as well as the actions and technologies companies are implementing to help achieve a brighter future for patients.

mRNA Process And Cost Modeling: A Tool To Optimize Process Development

Demand for mRNA-based medicine production continues to increase, as do investments in prophylactic and therapeutic indications. Explore a cost-model that compares all modalities.

Potent Immune Response With Vernal's LNP-mRNAs

As mRNA medicine continues to evolve, understand how trusted manufacturing partners will continue to play a pivotal role in translating innovative concepts into clinical reality.