Newsletter | May 22, 2024

05.22.24 -- The Critical Importance Of LNP Production Platforms

FEATURED EDITORIAL

“A Particular Set Of Skills:” Outsourcing Considerations For mRNA Therapeutics

By AR Welch, Editorial & Community Director, Advancing RNA

In the first of this two-part article series, Jain offers us his observations on the growth of the mRNA outsourcing sector, as well as the most important learnings he’s gleaned from engaging and contracting CDMOs in this space — particularly in these “earlier” days of the RNA therapeutics industry.

Unpacking The Importance Of Lipid Nanoparticle Production Platforms

Maik Jornitz, BioProcess Resources LLC

Batch processing platforms for LNPs lack efficiency, appropriate controls, and yield optimization. Continuous manufacturing platforms may address some of those issues.

A Deeper Look At What's Driving Dependence On Biotech Contract Manufacturers

By P. Bhendale, Markets and Markets

Are you struggling to find CDMO capacity? Here are some of the drivers behind the contract manufacturing market's exponential growth.

INDUSTRY INSIGHTS

Establishing Analytical Methods For mRNA-Based Therapies

White Paper | MilliporeSigma

Here, we provide a detailed description of assays for sequence identification and LNP composition in mRNA-LNP products that support the development of safe and effective mRNA therapies.

A Deeper Dive On Mitigating Financial Risk Before Selecting A Vendor

Webinar | inSeption Group

In part two of this webinar series, presenters focus on avoiding potential risks such as unexpected budget changes and unplanned change orders that could jeopardize the success of a clinical trial.

Effects Of mRNA Capping Technologies

Poster | By Christian Cobaugh, Kurtis Breger, et al., Vernal Biosciences

This study compares two important mRNA capping technologies by evaluating the mRNA integrity, percent Cap1 content, dsRNA content, in vivo expression, and innate immune activation in mice.

Optimized And Scalable LNP Composition For RNA Vaccine Delivery

Poster | By N. Orr, et al., Precision NanoSystems

Explore results from a study screening novel LNP formulations for physicochemical attributes, in vitro potency, and in vivo immunogenicity in both SARS-CoV-2 and influenza vaccine applications.

Navigating Challenges In Progressing Breakthrough RNA Therapeutics

Infographic | ReciBioPharm

RNA therapeutics hold immense promise for precision treatment, but their development faces challenges. A CDMO with adaptable platforms and flexible timelines can help reduce time and costs.