Scale-Up And Production Of Key Lipids Used In mRNA Delivery Systems

During the COVID-19 pandemic, mRNA vaccines demonstrated significant success, with lipid nanoparticles playing a crucial role in their effectiveness. These nanoparticles facilitate the entry of mRNA into cells, where it prompts the synthesis of spike proteins in the ribosomes. The formulation of these nanoparticles generally consists of four key components, with ionizable lipids and PEG lipids being particularly important. To meet the urgent demand for vaccines, large quantities of lipids were necessary, which required a rapid scale-up of production processes.

This webinar will delve into the industrialization requirements for producing ionizable and PEG lipids, focusing on the common challenges encountered in their manufacturing. Issues such as high molecular weight, the oily nature of pure substances, and the absence of a chromophore will be discussed, along with the purification and analytical hurdles that must be addressed during synthesis.