Newsletter | June 11, 2025

06.11.25 -- "Raiders Of The Lost Codon:" Alltrna On Evolving "Ancient" tRNA Into Therapeutics

SPONSOR

Webinar: Scaling up your E. coli pDNA process from parameter screening to pilot scale with advanced single-use bioreactors

Part 1 in an exciting 3-part webinar series to accelerate your pDNA and mRNA process development. Click here to learn more.

FEATURED EDITORIAL

The Potential Impact Of U.S. Tariffs On The Biotech Sector

Syner-G Biopharma Group's Raymond Forslund, Ph.D., MBA explores how U.S. tariffs might affect biotech manufacturing, funding, and clinical research.

The Price of Progress: Unlocking Cost Efficiencies in mRNA-LNP Production

In this final segment of an Advancing RNA Live discussion, panelists April Sena, Tyler Goodwin, and Adi Nair share the most meaningful and manageable improvements the industry can be making today to upstream and downstream processes to drive down mRNA-LNP COGS.

"Raiders Of The Lost Codon:" Alltrna On Evolving "Ancient" tRNA Into Therapeutics

Here, in part one of this two-part article, we identify how tRNA stands apart from other RNA modalities and gene therapies, as well as how this molecule’s unique “skill set” is guiding the company’s future clinical strategy.

INDUSTRY INSIGHTS

Improving Toxicology Testing For Inhalation Products

By embracing new approach methods, regulatory agencies can revolutionize toxicology testing. These methods can be adapted for various medications, including inhalers and nasal-administered drugs.

IR Spectral Signatures Of GC, AU, And GU Base Pairing In H2O-Based Buffer

Explore a label-free approach to characterize RNA structure with high sensitivity. See how specific base pair types are resolved, providing a clearer picture of RNA folding.

High-Throughput Lipid Separation For LNP Formulations

Lipid nanoparticles (LNPs) carry immense potential as delivery systems. Learn about the development of isocratic and gradient methods for high-throughput separation of lipids used in LNP formulations.

Modulate mRNA Therapy Effectiveness Using Modified Ribonucleotides

Learn about the problem of immunogenicity of mRNA, modified mRNA via in vitro transcription production, and choosing fit-for-purpose modified ribonucleotides.

Key Benefits Of PCR-Based mRNA Manufacturing For Clinical Development

To unlock the potential of your mRNA therapies and accelerate your development and manufacturing program, discover the benefits of a novel PCR-based mRNA drug substance manufacturing process.

Can mRNA Disrupt The Biopharma Industry?

mRNA has the potential to revolutionize the field of vaccine development. However, it is critical we understand any factors that could impact its successful entry into today’s market.

Fit-For-Purpose Lipids Can Accelerate, Scale, And Improve RNA-LNP Drugs

Emerging biotech companies are investing in novel delivery capabilities to address different modalities' needs and extra-hepatic delivery. Explore steps to accelerate commercial nanomedicine delivery.

The Current And Future Value Of mRNA Vaccines And Therapeutics

Discover how decades of research have propelled mRNA technology to the forefront of therapeutic development and learn how our expertise is advancing mRNA drug development.