Newsletter | April 30, 2025

04.30.25 -- Plasmid Production: 3 Takeaways For mRNA Manufacturing

SPONSOR

Join Advancing RNA Live for a dynamic discussion on the latest regulatory guidances from global agencies and what they mean for mRNA vaccine and therapeutic development. Discover key challenges, actionable insights, and best practices to accelerate your programs—no matter your approach. Don’t miss this opportunity to gain expert-driven clarity. Registration is free thanks to the support of Roche CustomBiotech.

FEATURED EDITORIAL

Plasmid Production: 3 Key Takeaways For mRNA Manufacturing

By AR Welch, Editorial & Community Director, Advancing RNA

Following my latest Live panel on analytical and manufacturing technology innovations for mRNA production, I wanted to provide a few high-level takeaways I gleaned from our discussion on the overlooked darling of the mRNA space: The plasmid. 

How HHS Budget Cuts And Vaccine Hesitancy Threaten Clinical Trial Operations — And What Leaders Can Do

By S. Lee, Johns Hopkins Carey Business School and Bloomberg School of Public Health

Prof. Stacey B. Lee, Ph.D., examines how the recent Department of Health and Human Services (HHS) staffing cuts and vaccine hesitancy combine to make clinical research much more challenging.

Synthetic pDNA: Is It Ready For mRNA Production Primetime?

Together, this Advancing RNA panel briefly addresses the ongoing rise of synthetic pDNA, sharing the current benefits and limitations of working with this technology for plasmid production today.

INDUSTRY INSIGHTS

Utilizing Nanoparticle Technologies For A More Sustainable Value Chain

e-book | Nanoform

The pharma industry is identifying ways to make processes more sustainable. Learn how nanoparticle engineering technology can both empower sustainability goals and lead to better patient outcomes.

CRISPR 101 - Your Guide To Understanding CRISPR

e-book | Synthego Corporation

Review the fundamentals of CRISPR technology, development, and its use to manipulate genes in different ways, such as altering their nucleotide sequences or changing their expression.

Assigning IR Absorption Bands For RNA Building Blocks Using MMS

Application Note | RedShiftBio

Explore the power of MMS in identifying RNA base signatures. This study analyzes vibrational modes of A, G, C, and U, revealing insights into electronic environments and molecular interactions.

End-To-End Cold Chain Management: A Next-Generation Approach

Webinar | Sartorius

Three experts in cold chain management walk through the advantages of end-to-end platforms for bulk drug substance management.

LNP Formulation For mRNA Delivery

Article | Cytiva

Microfluidic mixing is one of the most effective means to formulate LNPs for its scalability and reproducibility. Explore LNP formulation, polishing, sterile filtration of mRNA-LNPs, and more.

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The 5th mRNA-Based Therapeutics Summit returns to Boston as the world's largest, end-to-end mRNA conference, gathering 350+ global stakeholders, sharing exclusive scientific and strategic insights from the biggest and newest players in the mRNA field. Register now.