Nova™ Benchtop For Lipid Nanoparticle R&D And Pre-Clinical Development

Best For: Research and Development and lab-scale production

Mixing Technology Options:

-Helix Impinged Jet Mixers (IJMs)

-Microfluidic (MF) chip compatible

Nova™ BT is a flexible modular platform for lipid nanoparticle synthesis. Researchers can choose from a range of IJM mixers or utilize common and custom microfluidic chips while screening lipid compositions and optimizing RNA+LNP formulation process parameters affecting encapsulation, particle size and polydispersity, and stability.

The Nova™ Platform is a modular system which means that scaling up is as easy as adding modules (pump and/or mixer modules). Simply add a pump module and second mixing stage for in-line dilution or nanoparticle modification capabilities. For larger production capacity, blast through to the Nova Pilot High Throughput (HT) system.

Modules Components

• Pumps: Dual Pump Modules
• Single Pump Modules
• Mixing Modules
• Sample Collection Modules

Software and Control

• Custom User Interface
• Monitor and control formulation remotely or in-person via PC or laptop.

Formulation Optimization - Common Easily Tunable Parameters

• TFR - Total Flow Rate
• FRR - Flow Rate Ratio
• Process Startup/End Wastes, Priming Volumes

​Nova™ BT system with optional modular components

Scaleup Studies: moving from ≤1mL to ≥100mL

The default Nova™ BT platform including a dual pump module, single-stage mixer, and sample collector can be used to prepare samples as small as 100uL while also enabling scaleup to ≥ 100mL per run. The system provides a repeatable manufacturing process, allowing pooling of multiple batches to produce ≥ 1L of material. All Nova™ BT processes and mixing technologies are designed to facilitate seamless tech transfer and process scaleup with SuperNova™ High Throughput (HT) systems .