Newsletter | November 6, 2024

11.06.24 -- Mastering mRNA Manufacturing: A Focus On Raw Materials & Supply Assurance

SPONSOR

The Alliance for mRNA Medicines is hosting AMM ASCENT, its 1st Annual Meeting, on November 13-15 in Boston. The event brings together senior executives and decision-makers to advance mRNA research into vaccines and therapies for patients. Features include one-on-one partnering and networking opportunities, keynotes, and plenary/panel discussions among biotech, pharma, and academic leaders. Learn more and register here.

FEATURED EDITORIAL

A Tale Of Two Futures: Financial Trends Shaping The ATMP Space

In the first of this two-part article, I’ll share a few of the commercial nuances informing what the path forward may look like for all of us in the ATMP financial sector.

Mastering mRNA Manufacturing: A Focus On Raw Materials & Supply Assurance

Rapid advancements in mRNA-based therapeutic development have underscored the role of raw material quality and supply chain management in ensuring their successful production.

A New Approach To Genome Engineering With Tessera Therapeutics' Dr. Michael Severino

Tessera Therapeutics' CEO, Dr. Michael Severino, joins Host Erin Harris to discuss Gene Writing, the biotech's genome engineering technology that writes therapeutic messages into the genome to treat diseases at their source. Severino discusses why delivery has always been a challenge for gene editing technologies and why Gene Writing is different when it comes to efficient delivery.

INDUSTRY INSIGHTS

Enabling GMP Production Of sgRNA For CRISPR-Based Cell Therapies

Explore critical steps and key regulatory requirements for developing CRISPR therapeutics and gain practical advice on how to avoid common pitfalls.

Advantages Of Cas9 mRNA For Gene Editing

Discover why Cas9 mRNA is the preferred choice for precise gene editing, offering efficient delivery, transient expression, and flexible targeting.

Utilizing Nanoparticle Technologies For A More Sustainable Value Chain

The pharma industry is identifying ways to make processes more sustainable. Learn how nanoparticle engineering technology can both empower sustainability goals and lead to better patient outcomes.

LNP Formulation For mRNA Delivery

Microfluidic mixing is one of the most effective means to formulate LNPs for its scalability and reproducibility. Explore LNP formulation, polishing, sterile filtration of mRNA-LNPs, and more.

An Introduction And Brief History Of mRNA-LNPs

With adjustable components and increased stability during bloodstream circulation, LNPs are significantly advancing drug development and delivery, particularly for mRNA vaccines.

Regulatory Expertise For mRNA-Based Therapeutic Development

Explore the regulatory requirements for mRNA drug substances and products, the importance of phase-appropriate quality, and insights on creating CMC documentation to ensure compliance.

Transforming Drug Delivery

Learn how our team of scientists, engineers, and human-centered designers, as well as our world-class facilities, empower us to confidently guide your product toward a successful market launch.

SPONSOR

It’s impossible to attend an event on the future of RNA therapeutics without hearing about the challenges we’re facing with targeted RNA-LNP delivery. In this final Advancing RNA Live discussion of 2024, we sit down with three LNP experts to parse out the current opportunities and unknowns facing the development of next-generation LNPs. Secure your spot today! Registration is free thanks to the support of Helix Biotech.