Linear Scalability In Turbulent‐Jet Mixing For Nanoparticle Processing: Scientific Foundations And Advantages

Translating nanoparticle formulations from the lab to commercial scale is often fraught with unpredictable shifts in quality attributes like particle size and encapsulation efficiency. This challenge is overcome by linear scalability, the ability to preserve process dynamics and outcomes across different scales.

Turbulent-jet mixing, including coaxial turbulent jet mixers, is emerging as the essential technology enabling this predictability. By generating controlled, high-Reynolds-number fluid flows, this mixing method ensures that convective transport quickly dominates diffusion, a key factor in reproducible particle formation.

Scientific evidence shows that controlling factors like the Reynolds number and flow geometry maintains the same intense mixing physics from small research volumes to large, continuous, GMP-compatible production settings. This process robustness ensures consistent particle size, narrow distributions, and high encapsulation efficiency, drastically reducing development time and easing the path to regulatory approval.

Discover the scientific foundations and advantages of this technology for your nanoparticle projects.