Newsletter | December 18, 2024

12.18.24 -- "Ghosts of mRNA Past & Present:" 6 RNA Execs Revisit 2024

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FEATURED EDITORIAL

"Ghosts Of mRNA Past & Present": 6 RNA/LNP Execs Revisit 2024

But much like Dicken's “A Christmas Carol” with its emphasis on how the past and present inform the future, I was struck by six RNA executive’s appreciation for where we have been and currently are as an industry, and how these moments in time are already informing mRNA/RNA’s bright future.

Were We (Are We) Correct About Oligonucleotides?

In 2023, Chief Editor Louis Garguilo proclaimed it was "the year of oligonucleotides," and 2024 would be an incredible growth year for oligos. How are those proclamations panning out? He takes a detailed look, including the important role in the expected growth played by CDMOs.

RNA Therapeutics: New Market Research

According to our new market research, the RNA therapeutics industry is predicted to exceed $31 billion by 2032. This article shares key findings and trends.

Advancements In LNP CMC: What Are The Current "Known Knowns"?

In this Advancing RNA Live clip, Sanofi’s Sumit Luthra highlights the learnings we’ve made to-date about how our processes — both in terms of unit operations and process conditions — inform our LNP composition/heterogeneity.

INDUSTRY INSIGHTS

Gene-Edited CAR T Cells For Off-The-Shelf Cancer Therapy

We report on the use of a novel lipid nanoparticle (LNP) reagent in a validated protocol for complex gene editing in primary T cells with high efficiency while maintaining high cell viability.

Potent Immune Response With Vernal's LNP-mRNAs

As mRNA medicine continues to evolve, understand how trusted manufacturing partners will continue to play a pivotal role in translating innovative concepts into clinical reality.

Determining RNA Integrity And Purity By Capillary Gel Electrophoresis

To ensure mRNA product quality, it's important to confirm the integrity of the RNA. Examine the results of a study challenging the performance of the CGE method in assessing mRNA integrity and purity.

PEG In LNP Formulations: Addressing Challenges And Seeking Solutions

Polyethylene glycol and similar variants have driven innovative research for therapies. However, the continued use of PEG poses significant drawbacks.

Ophthalmic Drug Delivery

Explore the challenges to effective delivery of drugs to the eye, intricacies of ophthalmic drug delivery, and advantages of nanoparticles as an enabling technology for ocular drug-delivery systems.

Compatible Platforms For Microbial Identification

Reduce the time-to-results for microbial identification by taking advantage of the shorter run cycle and off-instrument data analysis provided by this optimized and validated workflow.

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2025 BioPlan's 22nd Annual Survey--Biopharmaceutical Manufacturing

For over 20 years, we continue to be the leader in providing the biopharma industry's most comprehensive benchmarking analysis. We invite you to participate in our 22nd Annual Survey in Biopharmaceutical Manufacturing! For all completed, qualified responses, we'll send an Amazon egift card, a copy of the summary results (mid-2025), and our 2025 Top Trends in Biomanufacturing White Paper.