Newsletter | September 30, 2026

09.30.26 -- dsRNA Removal: A New Purification Strategy

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What will define the next generation of RNA therapeutics? This collection brings together industry experts to examine the innovations transforming RNA development, from advanced delivery systems and AI-enabled discovery to manufacturing scale-up and regulatory readiness. Gain valuable insights into emerging applications across oncology, vaccines, gene editing, and personalized medicine while exploring the challenges and opportunities shaping the future of the field. Click to learn more.

FEATURED EDITORIAL

Outgrowing Legacy Methods: mRNA's Transition From Protein Paradigms

AbbVie’s Elaine Peters, Sanofi’s Philippe Talaga, and Tessera’s Ilya Shestopalov highlight the technical limitations of legacy analytical methods in evaluating and measuring mRNA-LNP concentration, structure, purity, integrity, and impurities.

 

The Second Holy Grail Of Gene Editing: Large Knock-Ins

Exploring the race to achieve large gene knock-ins, emerging editing platforms, and how overcoming this challenge could unlock therapies for many inherited diseases.

 

A New Purification Strategy For The Removal Of dsRNA Impurities From IVT mRNA Products

NIST research introduces a gentle SEC method that separates dsRNA impurities from IVT mRNA by tweaking buffer pH, achieving 81.8% target recovery without transcript damage.

 

Analytical Platforms: The Foundation Of The Next Generation Of RNA Therapeutics

RNA therapeutics are entering a new era where analytical platforms drive scalability, regulatory confidence, manufacturing flexibility, and the development of increasingly complex products.

 

INDUSTRY INSIGHTS

 

Cost Transparency In The R&D Partnership Landscape

Opaque pricing slows decisions and erodes trust. Transparency clarifies cost drivers, improves budgeting, enables confident sourcing, and strengthens long-term R&D partnerships.

 

Elevating mRNA Manufacturing Toward GMP-Readiness

The mRNA Technology Transfer Program expands LMIC manufacturing capabilities. Discover how strategic industry collaboration creates a reliable, equitable model for global health access.

 

Protecting Cold Chain Quality For Expanded Clinical Trials

Moving to frozen starting materials stabilizes critical inputs, yet isolated workflows invite risk. Integrated logistics strategies shield quality as clinical trial footprints expand.

 

Engaging Early In Process Development To Bring mRNA Sequences To Life

Examine why template sequence characteristics are relevant for cGMP manufacturing of high-quality mRNA and consider strategies for developing a scalable, robust, and economically viable process.

 

Research-Scale Oligonucleotide Workflow

Get a clear view of oligonucleotide development from synthesis to purification and filtration with practical insights to help you streamline workflows and stay ahead in the fight against disease.

 

dsRNA Formation And How RNA Polymerase Choice Can Reduce It

T7 polymerase generates substantial double-stranded RNA in IVT reactions. Non-T7 alternatives tell a different story, and the data make a compelling case for reconsidering your enzyme selection.

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Cell 2026 | 12-13 November, London, UK

Advanced therapy development moves fast, and the companies shaping it are the ones connecting science, scale and strategy in the same room. Cell 2026 is where that happens. Partner with us to reach 800+ senior pharma, biotech and R&D decision-makers through guaranteed 1:1 meetings, speaking slots, roundtables and tailored digital campaigns. Get in touch and we'll design a package around your objectives.

SOLUTIONS

mRNA Raw Materials: Supporting Your Journey To Market

Improve Purity, Recovery, And Consistency In Your Oligonucleotide Workflow

Realize The Full Potential Of Your RNA Therapeutics