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| Purifying large mRNA molecules (>500 nt) is challenging due to strong multi-point binding and the formation of highly complex quaternary structures with other mRNA transcripts. Our advanced anion exchange chromatography (AEX) method optimizes pH, salt, and chaotropic conditions to enable high-yield purification at ambient temperatures. This scalable approach ensures efficient separation of double-stranded and single-stranded RNA while maintaining product integrity. Additionally, it enhances impurity removal, including aggregates and DNA/RNA-hybrids, meeting stringent quality standards. Learn more. |
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By Philip Probert, CPI | Gene therapies and nucleic acid medicines are dependent upon a starting DNA template that defines the protein or antigen. The sequence of this template DNA being correct is critical. | |
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In this snippet, panelist Alex Aust (with the help of several live attendee commenters) tackles a particularly tricky question: Are our outsourcing partnerships producing high quality products today, and what are the most common root causes of batch failures? |
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| Empowering A New Era Of Patient-Centric Medicines | Podcast | Nanoform | Explore the challenges pharma companies are facing as they switch focus as well as the actions and technologies companies are implementing to help achieve a brighter future for patients. |
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| The Current And Future Value Of mRNA Vaccines And Therapeutics | White Paper | By Norman Garceau, Ph.D., Jordon Wang, Ph.D., and Scott Alderucci, Curia | Examine how decades of research have propelled mRNA technology to the forefront of therapeutic development and learn how our expertise is advancing mRNA drug development. |
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