Development Of A Mitra Tip Extraction Assay Coupled With LC-MSMS

In this video, Shawn Burton, Principal Analytical Investigator, breaks down a scientific poster detailing a novel approach for quantifying crucial biomarkers like L-Citrulline, L-Arginine, and L-Argininosuccinic Acid. These biomarkers are vital for understanding various physiological processes and pathological conditions. However, their accurate measurement is challenging due to low concentrations and sample complexity.

The poster highlights a new method using Mitra tip extraction combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS). This technique offers a convenient and reproducible way to extract these biomarkers from biological matrices, especially from small blood volumes typically available in mouse models. Mitra tips simplify sample collection while LC-MS/MS ensures accurate quantification. Watch the video to learn more about this innovative approach to biomarker analysis.