CRISPR Base And Prime Editing mRNA

Precise genome editing requires tools that balance flexibility, efficiency, and control. Base editing enables targeted A-T to G-C conversions without creating double-strand DNA breaks or requiring donor DNA templates, while prime editing expands the possibilities to precise substitutions, insertions, and deletions. Aldevron, in partnership with Integrated DNA Technologies (IDT), brings together optimized mRNA editors and highly modified guide RNAs to support both approaches.

Explore ABE8e base editor mRNAs with multiple PAM options for greater targeting flexibility, as well as PE Ultra mRNA and Alt-R™ pegRNAs designed to support efficient prime editing workflows. Data demonstrate base conversion across immortalized and primary cell types and compare PE Ultra editing efficiency with commercially available PEmax.

See how these solutions can help researchers advance precision genome editing from experimental design through execution.