AxiChrom™ Chromatography Columns

Source: Cytiva

The AxiChrom™ column platform is a revolutionary concept in column chromatography that simplifies column handling at all scales from process development to full-scale production in GMP environments.

AxiChrom columns introduce three key features – Intelligent Packing, intuitive handling, and predictable scale-up – that together make process chromatography easier, safer, and more efficient.

Intelligent Packing: Verified, preprogrammed, axial compression packing methods save time and ensure accurate and reproducible packing results. This built-in experience reduces operator dependence and facilitates faster product change-over. Intelligent packing is supported on ÄKTA avant™ 150, ÄKTA pilot™ 600, and ÄKTA process™ systems across the entire AxiChrom column family.

Intuitive handling: Columns are simple to operate and service. Pivot or swing-out column tubes are safer and easier to handle. AxiChrom column control unit and UNICORN™ wizards guide users through key process steps to save time in method creation, operation, and maintenance.

Predictable scale-up: Scale-up and tech transfer are straightforward due to a liquid distribution system designed using the same analytical and computational fluid dynamic (CFD) modeling tools. Sanitizable columns support cleaning validation. Full technical and regulatory support promotes fast, trouble-free start-up. The entire AxiChrom column line, from 50 to 1600 mm, has been verified to give reproducible performance with modern high-flow Capto™ and MabSelect™ chromatography resin families as well as with other BioProcess™ resins. Custom sizes up to 2000 mm are available.