07.03.26 -- Advancing RNA Newsletter Best Of June

Join Advancing RNA Live Chief Editor Anna Rose Welch and expert panelists on July 9 at 11 AM ET. for the live virtual event: The mRNA Therapeutics Regulatory Paradigm: A Closer Look. This discussion is free thanks to event sponsor Roche CustomBiotech. Can't join live? No problem. Register today and reserve your link for the On Demand connection.

To be clear, this year’s USP/AMM quality forum was just as focused on the intricacies of applying/using the methods. But what was equally if not more present in this year’s discussion was our increasing acknowledgement that our understanding of mRNA and its biological mechanisms remains quite messy.

Is the future of RNA manufacturing fully enzymatic? In this Advancing RNA Live clip, panelists Claire MacCleod and Jill Caswell unpack why the "hybrid" chemoenzymatic approach is an essential bridge to an enzymatic future for siRNA production. 

In this Advancing RNA Live clip, CPI’s Claire MacCleod shares the biological and logistical hurdles currently keeping full enzymatic production of siRNA at bay. 

Discover essential considerations for scaling RNA production to commercial manufacturing. Master the technical processes behind both messenger RNA and self-amplifying RNA.

Review the regulatory classification of LNPs, liposomes, and novel excipients. This guide outlines specific global guidance documents and strategic frameworks to overcome compliance challenges.

New technologies for the encapsulation of nucleic acids can potentially overcome current limitations of standard mixing methods, offering researchers a more reliable path to production.