Advancements in gRNA Manufacturing & Quality

Guide RNA is a critical component of a gene editing therapy. However, the current manufacturing (solid phase synthesis) and analytical paradigms remain insufficient for such large, complex molecules. In this discussion, Life Edit's April Sena, Genentech's Max De Long, and Flashpoint Therapeutics' Venkat Krishnamurthy dug into where the biggest gaps remain in our understanding of guide RNA quality and what improvements to the manufacturing paradigm need to be made to improve the overall yield and quality of guide RNA.