Addressing Challenges In mRNA Drug Development And Manufacturing

mRNA therapeutic strategies are gaining renewed interest in the wake of the rapid development and approval of COVID-19 vaccines. mRNA-based drug products serve as an ideal platform for use in infectious disease, protein replacement, and immuno-oncology applications due to the simplicity of manufacturing and robust immune response.

However, obstacles persist around designing the template mRNA to properly balance the innate immune response with making a robust amount of protein, and ensuring the route of administration and vaccine form enable the desired therapeutic response while meeting storage and logistical requirements. Download the interactive article in PDF to learn more about best practices for optimizing mRNA stability and protein expression and how to produce efficacious, high-quality advanced therapeutics.